| Nutrient-gene interactions in early pregnancy: a vascular hypothesis. | |
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MedLine Citation:
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PMID: 12551774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is hypothesized that the following periconceptional and early pregnancy nutrient-gene interactions link vascular-related reproductive complications and cardiovascular diseases in adulthood: (1) Maternal and paternal genetically controlled nutrient status affects the quality of gametes and fertilization capacity; (2) The embryonic genetic constitution, derived from both parents, and the maternal genetically controlled nutrient environment determine embryogenesis and fetal growth; (3) Trophoblast invasion of decidua and spiral arteries is driven by genes derived from both parents as well as by maternal nutritional factors; (4) Angiogenesis, vasculogenesis and vascular function are dependent on the genetic constitution of the embryo, derived from both parents, and the maternal genetically controlled nutritional environment.Early intra-uterine programming of vessels may concern the same (in)dependent determinants of vascular-related complications during pregnancy and cardiovascular diseases in later life. |
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Authors:
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R P M Steegers-Theunissen; E A P Steegers |
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Publication Detail:
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Type: Editorial |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 106 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-28 Completed Date: 2003-11-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 115-7 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Embryonic and Fetal Development
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genetics,
physiology* Female Humans Male Maternal-Fetal Exchange / genetics, physiology Neovascularization, Physiologic / genetics, physiology* Nutritional Status / genetics, physiology* Placental Circulation / genetics, physiology Pregnancy Pregnancy Complications Pregnancy Trimester, First / genetics, physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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