| Nutrient-gene interactions determine mitochondrial function: effect of dietary fat. | |
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MedLine Citation:
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PMID: 9472989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect on mitochondrial respiration of feeding hydrogenated coconut oil, corn oil, or menhaden oil (MO) to diabetes-prone BHE/cdb rats and normal Sprague Dawley (SD) rats was studied. Both fat source and strain affected the temperature dependence of succinate-supported respiration. The transition temperature was greater in BHE/cdb rats than in the SD rats. The efficiency of ATP synthesis as reflected by the ADP:O ratio was decreased in the BHE/cdb rats compared to SD rats, with the exception of the comparison made at 37 degrees C with the MO-fed rats; at this temperature, the ADP:O ratios were similar. The diet and strain differences suggest a dietary lipid-gene interaction with respect to the mobility of subunit 6 of the F1F0ATPase. This subunit has two errors in its gene: one that affects the proton channel and another that likely affects its mobility within the inner mitochondrial membrane. |
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Authors:
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M J Kim; C D Berdanier |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 12 ISSN: 0892-6638 ISO Abbreviation: FASEB J. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-02-27 Completed Date: 1998-02-27 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 8804484 Medline TA: FASEB J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 243-8 Citation Subset: IM |
Affiliation:
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Department of Foods and Nutrition, University of Georgia, Athens 30602-3622, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cocos Corn Oil / pharmacology Diabetes Mellitus, Type 2 / genetics, metabolism Dietary Fats / pharmacology* Disease Susceptibility Fish Oils / pharmacology Intracellular Membranes / metabolism Kinetics Male Mitochondria, Liver / metabolism* Oxidative Phosphorylation Oxygen Consumption / drug effects Plant Oils / pharmacology Proton-Translocating ATPases / genetics*, metabolism Rats Rats, Mutant Strains Rats, Sprague-Dawley Thermodynamics |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fish Oils; 0/Plant Oils; 8001-30-7/Corn Oil; 8001-31-8/coconut oil; 8002-50-4/Menhaden oil; EC 3.6.3.14/Proton-Translocating ATPases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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