| Nutrient-enhanced diet reduces noise-induced damage to the inner ear and hearing loss. | |
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MedLine Citation:
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PMID: 21708355 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Oxidative stress has been implicated broadly as a cause of cell death and neural degeneration in multiple disease conditions; however, the evidence for successful intervention with dietary antioxidant manipulations has been mixed. In this study, we investigated the potential for protection of cells in the inner ear using a dietary supplement with multiple antioxidant components, which were selected for their potential interactive effectiveness. Protection against permanent threshold shift (PTS) was observed in CBA/J mice maintained on a diet supplemented with a combination of β-carotene, vitamins C and E, and magnesium when compared with PTS in control mice maintained on a nutritionally complete control diet. Although hair cell survival was not enhanced, noise-induced loss of type II fibrocytes in the lateral wall was significantly reduced (P < 0.05), and there was a trend toward less noise-induced loss in strial cell density in animals maintained on the supplemented diet. Taken together, our data suggest that prenoise oral treatment with the high-nutrient diet can protect cells in the inner ear and reduce PTS in mice. The demonstration of functional and morphologic preservation of cells in the inner ear with oral administration of this antioxidant supplemented diet supports the possibility of translation to human patients and suggests an opportunity to evaluate antioxidant protection in mouse models of oxidative stress-related disease and pathology. |
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Authors:
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Colleen G Le Prell; Patricia M Gagnon; David C Bennett; Kevin K Ohlemiller |
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Publication Detail:
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Type: Journal Article Date: 2011-03-21 |
Journal Detail:
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Title: Translational research : the journal of laboratory and clinical medicine Volume: 158 ISSN: 1878-1810 ISO Abbreviation: Transl Res Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101280339 Medline TA: Transl Res Country: United States |
Other Details:
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Languages: eng Pagination: 38-53 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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University of Florida, Gainesville, Fla. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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