Document Detail


Nutrient acquisition by pathogenic fungi: Nutrient availability, pathway regulation, and differences in substrate utilization.
MedLine Citation:
PMID:  21550848     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
All pathogenic microorganisms have in common that they need to feed on nutrients available from their host. Therefore, the specific interruption of metabolic pathways is a promising approach which could lead to the discovery of new antimicrobial drugs. However, nutrient availability strongly varies in respect to the infected host niche and pathogens may possess different strategies to acquire nutrients. This review focuses on the differences in regulation and use of key metabolic pathways during infection by pathogenic fungi, especially in the filamentous fungus Aspergillus fumigatus and the dimorphic yeast Candida albicans. Besides universal metabolic pathways, emphasis is given on pathways, which are absent in humans and might, therefore, suit as antifungal drug targets. Niche-specific nutrient availability and different physiological strategies complicate the identification of metabolic pathways, which are essential for all pathogens at each step of the infection process.
Authors:
Christian B Fleck; Felicitas Schöbel; Matthias Brock
Related Documents :
22493658 - Uptake and accumulation of oxidized low-density lipoprotein during mycobacterium tuberc...
3683168 - Natural abundance 13c nmr spectrum of glycogen in humans.
14110758 - Metabolic studies with di(aziridin-1-yl) sulphoxide (diethyleneiminosulphoxide).
21476568 - Comparative study of hops-containing products on human cytochrome p450-mediated metabol...
21059418 - The immense potential of xenotransplantation in surgery.
3183158 - Changes of secretory ameloblasts in mini-pig fetuses exposed to ethanol in vivo.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-6
Journal Detail:
Title:  International journal of medical microbiology : IJMM     Volume:  -     ISSN:  1618-0607     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898849     Medline TA:  Int J Med Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier GmbH. All rights reserved.
Affiliation:
Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Microbial Biochemistry and Physiology, Beutenbergstr. 11a, 07745 Jena, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The parasitophorous vacuole of Encephalitozoon cuniculi: Biogenesis and characteristics of the host ...
Next Document:  Genetic susceptibility to Aspergillus fumigatus infections.