Document Detail

Nutrient accretion in preterm infants fed formula with different protein:energy ratios.
MedLine Citation:
PMID:  9226525     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although standard formulas for preterm infants promote intrauterine rates of weight gain, fat deposition in preterm infants fed these formulas has been reported to be considerably higher than that in the fetus. We hypothesized that a preterm infant formula with a higher protein:energy (P:E) ratio would promote accretion rates of fat, fat-free mass, and minerals closer to those of the fetus. METHODS: As part of a larger study to determine whether accretion rates of fat and fat-free mass closer to those of the fetus can be achieved with a higher P:E ratio, we present a descriptive analysis of 72-h nutrient balance studies performed on a subset (n = 15/30) of the infants randomly assigned to be fed formula with a P:E ratio of either 3.2 g/100 kcal or 2.6 g/100 kcal. RESULTS: Despite the higher intake and net absorption of nitrogen by infants fed the higher P:E formula, there was no statistically significant difference in net nitrogen retention between groups. There also were no statistically significant differences between groups in digestible energy, metabolizable energy, energy expenditure, or energy storage. Thus, partitioning of stored energy as protein and fat did not differ between groups. The retention of calcium, phosphorus, sodium, potassium, copper, and zinc also did not differ between groups, and nitrogen intake did not affect mineral retention. CONCLUSIONS: In this study, formula for preterm infants with a P:E ratio of 3.2 g/100 kcal vs. 2.6 g/100 kcal provided no apparent benefit in terms of the proportion of fat to lean tissue accretion as determined from nutrient balance data.
A K Fairey; N F Butte; N Mehta; M Thotathuchery; R J Schanler; W C Heird
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  25     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-11-18     Completed Date:  1997-11-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-45     Citation Subset:  IM    
Southern Mississippi Neonatology, Hattiesburg, USA.
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MeSH Terms
Calcium / blood,  metabolism
Cohort Studies
Copper / metabolism
Dietary Fats / metabolism
Dietary Proteins / administration & dosage*
Energy Intake / physiology*
Energy Metabolism / physiology
Infant Food* / analysis,  standards
Infant Nutritional Physiological Phenomena*
Infant, Low Birth Weight / blood,  physiology*
Infant, Newborn
Infant, Premature / blood,  physiology*
Magnesium / blood,  metabolism
Minerals / metabolism
Nitrogen / metabolism
Phosphorus / blood,  metabolism
Potassium / metabolism
Sodium / metabolism
Zinc / metabolism
Grant Support
M01 RR-00188-30/RR/NCRR NIH HHS
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Proteins; 0/Minerals; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-50-8/Copper; 7440-66-6/Zinc; 7440-70-2/Calcium; 7723-14-0/Phosphorus; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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