Document Detail

A nutrient-wide association study on blood pressure.
MedLine Citation:
PMID:  23093587     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A nutrient-wide approach may be useful to comprehensively test and validate associations between nutrients (derived from foods and supplements) and blood pressure (BP) in an unbiased manner.
METHODS AND RESULTS: Data from 4680 participants aged 40 to 59 years in the cross-sectional International Study of Macro/Micronutrients and Blood Pressure (INTERMAP) were stratified randomly into training and testing sets. US National Health and Nutrition Examination Survey (NHANES) four cross-sectional cohorts (1999-2000, 2001-2002, 2003-2004, 2005-2006) were used for external validation. We performed multiple linear regression analyses associating each of 82 nutrients and 3 urine electrolytes with systolic and diastolic BP in the INTERMAP training set. Significant findings were validated in the INTERMAP testing set and further in the NHANES cohorts (false discovery rate <5% in training, P<0.05 for internal and external validation). Among the validated nutrients, alcohol and urinary sodium-to-potassium ratio were directly associated with systolic BP, and dietary phosphorus, magnesium, iron, thiamin, folacin, and riboflavin were inversely associated with systolic BP. In addition, dietary folacin and riboflavin were inversely associated with diastolic BP. The absolute effect sizes in the validation data (NHANES) ranged from 0.97 mm Hg lower systolic BP (phosphorus) to 0.39 mm Hg lower systolic BP (thiamin) per 1-SD difference in nutrient variable. Inclusion of nutrient intake from supplements in addition to foods gave similar results for some nutrients, though it attenuated the associations of folacin, thiamin, and riboflavin intake with BP.
CONCLUSIONS: We identified significant inverse associations between B vitamins and BP, relationships hitherto poorly investigated. Our analyses represent a systematic unbiased approach to the evaluation and validation of nutrient-BP associations.
Ioanna Tzoulaki; Chirag J Patel; Tomonori Okamura; Queenie Chan; Ian J Brown; Katsuyuki Miura; Hirotsugu Ueshima; Liancheng Zhao; Linda Van Horn; Martha L Daviglus; Jeremiah Stamler; Atul J Butte; John P A Ioannidis; Paul Elliott
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-23
Journal Detail:
Title:  Circulation     Volume:  126     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-21     Completed Date:  2013-01-18     Revised Date:  2014-08-05    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2456-64     Citation Subset:  AIM; IM    
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MeSH Terms
Alcohol Drinking / blood,  epidemiology
Biological Markers
Blood Pressure / physiology*
Cohort Studies
Cross-Sectional Studies
Energy Intake / physiology
Micronutrients / administration & dosage*,  blood*
Middle Aged
Nutrition Surveys / methods*
Nutritional Status*
Potassium, Dietary / administration & dosage,  blood
Sodium, Dietary / administration & dosage,  blood
Vitamin B Complex / administration & dosage,  blood
Grant Support
G0801056//Medical Research Council; R01 HL050490/HL/NHLBI NIH HHS; R01 HL065461/HL/NHLBI NIH HHS; R01 HL084228/HL/NHLBI NIH HHS; R01 HL084228/HL/NHLBI NIH HHS; R01 HL50490/HL/NHLBI NIH HHS; R01 HL65461/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Micronutrients; 0/Potassium, Dietary; 0/Sodium, Dietary; 12001-76-2/Vitamin B Complex
Comment In:
Circulation. 2012 Nov 20;126(21):2447-8   [PMID:  23093588 ]

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