| Nutrient specific feeding and endocrine effects of jejunal infusions. | |
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MedLine Citation:
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PMID: 20134410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal nutrient infusions result in variable decreases in food intake and body weight based on the nutrient type and the specific intestinal infusion site. Only intrajejunal infusions of fatty acids decrease food intake beyond the calories infused. To test whether this extra-compensatory decrease in food intake is specific to fatty acids, small volume intrajejunal infusions of glucose (Glu) and casein hydrolysate (Cas), as well as linoleic acid (LA) were administered to male Sprague-Dawley rats. Equal kilocalorie (kcal) loads of these nutrients (11.4) or vehicle were infused into the jejunum over 7 h/day for five consecutive days. Food intake was continuously monitored and body weight was measured daily. After the infusion on the final day, rats were killed and plasma collected. Intrajejunal infusions of LA and Glu, but not Cas, suppressed food intake beyond the caloric load of the infusate with no compensatory increase in food intake after the infusion period. Rats receiving LA and Glu infusions also lost significant body weight across the infusion days. Plasma glucagon-like peptide-1 (GLP-1) was increased in both the LA and Glu rats compared with control animals, with no significant change in the Cas-infused animals. Peptide YY (PYY) levels increased in response to LA and Cas infusions. These results suggest that intrajejunal infusions of LA and Glu may decrease food intake and body weight via alterations in GLP-1 signaling. Thus, particular nutrients are more effective at producing decreases in food intake, body weight, and inducing changes in peptide levels and could lead to a novel therapy for obesity. |
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Authors:
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Megan J Dailey; Kellie L K Tamashiro; Chantelle E Terrillion; Timothy H Moran |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-02-04 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 18 ISSN: 1930-739X ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-07-21 Revised Date: 2013-01-14 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 904-10 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. mdailey5@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Body Weight / drug effects* Caseins / administration & dosage* Eating / drug effects* Energy Intake / drug effects Enzyme-Linked Immunosorbent Assay Glucagon-Like Peptide 1 / blood Glucose / administration & dosage* Jejunum / drug effects* Leptin / blood Linoleic Acid / administration & dosage* Male Peptide YY / blood Radioimmunoassay Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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DK-19302/DK/NIDDK NIH HHS; K99 HD055030/HD/NICHD NIH HHS; MH-15330/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Caseins; 0/Leptin; 106388-42-5/Peptide YY; 2197-37-7/Linoleic Acid; 50-99-7/Glucose; 89750-14-1/Glucagon-Like Peptide 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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