Document Detail

Nutraceuticals for blood pressure control in patients with high-normal or grade 1 hypertension.
MedLine Citation:
PMID:  22994579     Owner:  NLM     Status:  In-Data-Review    
Background: Current hypertension management guidelines do not recommend drug treatment in subjects with blood pressure (BP) in the high-normal range due to the risk of side effects of the currently available antihypertensive agents that overcomes the possible benefit. Nutraceuticals are free from relevant side effects and could be a valuable strategy for the treatment of these patients. Aim: The objective of this study was to compare the efficacy of two nutraceutical compositions given by the combination of policosanol, red yeast rice extract, berberine, folic acid and coenzyme Q(10) with or without Orthosiphon stamineus in lowering the BP and lipid profile. Methods: Thirty patients with grade 1 essential hypertension and low cardiovascular risk were analysed. At the end of a run-in period, patients were divided into two study arms and assigned to receive the nutraceutical combination with and without Orthosiphon stamineus. All participants underwent 24-hour ambulatory BP monitoring at the end of the run-in period and of the 4-week treatment with each of the two different nutraceutical combinations. Results: In patients treated with Orthosiphon stamineus a significant reduction of mean 24-hour systolic and diastolic BP levels compared with baseline values was registered and the smoothness index calculated for systolic and diastolic BP showed a more reliable and homogeneous effect on BP over 24 hours. In contrast, nutraceutical treatment without Orthosiphon stamineus was not associated with a significant reduction of BP. Conclusions: Our results show that the addition of Orthosiphon stamineus to the combination of nutraceuticals confers an antihypertensive effect that allows a surprisingly effective 24-hour BP control in hypertensive patients. Received for publication 29 March 2012; Accepted for publication 4 May 2012.
Valentina Trimarco; Claudia Sara Cimmino; Mario Santoro; Gianpiero Pagnano; Maria Virginia Manzi; Anna Piglia; Caterina Anna Giudice; Nicola De Luca; Raffaele Izzo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension     Volume:  19     ISSN:  1179-1985     ISO Abbreviation:  High Blood Press Cardiovasc Prev     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421087     Medline TA:  High Blood Press Cardiovasc Prev     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  IM    
Department of NeuroSciences, Federico II University, Naples, Italy.
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