Document Detail


Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides.
MedLine Citation:
PMID:  20409714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As the sole nutrition provided to infants, bioactive molecules dissolved in milk influence the development of our gut microbiota. Accordingly, human milk oligosaccharides (HMOs) are minimally digested by the infant and persist to negatively and positively regulate gut microbiota. Infant-type bifidobacteria utilize these soluble carbohydrate oligomers by convergent mechanisms. Bifidobacterium longum subsp. infantis efficiently consumes several small mass HMOs and possesses a large gene cluster and other loci dedicated to HMO metabolism. In contrast, adult-associated bifidobacteria such as the closely related B. longum subsp. longum are deficient for HMO utilization, although they retain the capacity to ferment plant oligosaccharides and constituent pentose sugars. Thus, the ability to subsist on HMO could demark infant-associated ecotypes potentially adapted to colonize the nursing infant.
Authors:
David A Sela; David A Mills
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2010-04-19
Journal Detail:
Title:  Trends in microbiology     Volume:  18     ISSN:  1878-4380     ISO Abbreviation:  Trends Microbiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-10-07     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  9310916     Medline TA:  Trends Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  298-307     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Bifidobacterium / growth & development,  metabolism*
Gastrointestinal Tract / microbiology*
Humans
Infant
Infant, Newborn
Metabolic Networks and Pathways / genetics*
Milk, Human / chemistry*
Oligosaccharides / metabolism*
Grant Support
ID/Acronym/Agency:
1R01HD061923/HD/NICHD NIH HHS; 5R01HD059127/HD/NICHD NIH HHS; R01 HD059127/HD/NICHD NIH HHS; R01 HD059127-01/HD/NICHD NIH HHS; R01 HD059127-02/HD/NICHD NIH HHS; R01 HD061923/HD/NICHD NIH HHS; R01 HD061923-01/HD/NICHD NIH HHS; T32-GM08799/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Oligosaccharides
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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