Document Detail

Numerically optimized experiment design for measurement of grey/white matter metabolite T2 in high-resolution spectroscopic images of brain.
MedLine Citation:
PMID:  7743075     Owner:  NLM     Status:  MEDLINE    
T2 relaxation measurements for choline (Cho), total creatine (Cr = creatine + phosphocreatine), and N-acetylaspartate (NAA) were made separately in eight healthy volunteers using an average of forty 0.5 cc volumes (20 from grey matter and 20 from white matter) in spectroscopic images with a 32 x 32 resolution and a 240 mm field of view. In grey matter, the means and standard deviations of the T2 values were 186 +/- 23, 149 +/- 10, and 232 +/- 15 ms for Cho, Cr, and NAA, respectively, and in white matter, the mean T2 values were 178 +/- 16, 143 +/- 8, and 228 +/- 16 ms, respectively, with no significant differences between grey and white matter. The high-resolution measurements of T2 values were possible because of experimental planning based on the minimization of predicted fitting uncertainties. Explicit expressions were derived to estimate the uncertainties in T2 values, and it was found that two spectroscopic images with echo times of 50 and 250 ms, respectively, would yield sufficient precision for T2 measurements. The derivation of the expressions, a discussion of their behavior, and the experimental planning and verification are presented.
G F Mason; G M Pohost; H P Hetherington
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of magnetic resonance. Series B     Volume:  107     ISSN:  1064-1866     ISO Abbreviation:  J Magn Reson B     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-06-12     Completed Date:  1995-06-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9309764     Medline TA:  J Magn Reson B     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-73     Citation Subset:  IM    
Department of Medicine, University of Alabama at Birmingham 35294, USA.
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MeSH Terms
Aspartic Acid / analogs & derivatives,  metabolism
Brain / metabolism*
Choline / metabolism
Creatinine / metabolism
Magnetic Resonance Spectroscopy / methods*
Grant Support
Reg. No./Substance:
56-84-8/Aspartic Acid; 60-27-5/Creatinine; 62-49-7/Choline; 997-55-7/N-acetylaspartate
Erratum In:
J Magn Reson B 1996 Mar;110(3):321

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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