| Numerical study of oxygen transport in a carotid bifurcation. | |
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MedLine Citation:
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PMID: 20577040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigates the oxygen mass transport in the region around the human carotid bifurcation, particularly addressing the effects of bifurcation geometry and pulsatile blood flow on the oxygen transport between the blood flow and artery wall tissue, coupled with the metabolic oxygen consumption and oxygen diffusion in the artery wall tissue. The temporal variations and spatial distributions of the oxygen tension are predicted quantitatively using a geometric model of the human carotid bifurcation and realistic blood flow waveforms. Results reveal that the flow separation at the outside wall of the sinus of the internal carotid artery (ICA) can markedly alter the flow pattern, oxygen tension and the oxygen wall flux. Results also clarify that the flow unsteadiness has a secondary effect on the oxygen tension inside the wall. The non-dimensional oxygen flux, the Sherwood number Sh, at the outside wall of the ICA sinus, takes markedly lower values of about 45 than at other sites because the rates of oxygen transport by the convective flow are reduced at the outside wall of the ICA sinus. The transverse distributions of the oxygen tension inside the artery wall show parabolic profiles having minima in the middle of the wall thickness, with the lowest value of 35 mmHg. These predicted distributions of the oxygen tension inside the wall closely resemble those obtained from experiments. The results demonstrate that hypoxic zones appear inside the artery walls at locations where atherosclerotic lesions are prone to develop. |
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Authors:
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Shigeru Tada |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-24 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 55 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-06 Completed Date: 2010-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 3993-4010 Citation Subset: IM |
Affiliation:
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Department of Applied Physics, National Defense Academy, 1-10-20 Hashirimizu, Yokosuka city, Kanagawa 239-8686, Japan. stada@nda.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Anoxia / metabolism, pathology Carotid Arteries / anatomy & histology*, metabolism* Carotid Artery Diseases / metabolism, pathology Carotid Artery, Internal / anatomy & histology, metabolism Computer Simulation* Dogs Humans Models, Cardiovascular* Organ Size Oxygen / metabolism* Periodicity Regional Blood Flow Time Factors |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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