| Numerical study of the influence of anastomotic configuration on hemodynamics in miller cuff models. | |
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MedLine Citation:
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PMID: 19082894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Enhanced hemodynamics via geometric alteration is believed to play a role in the favorable redistribution of intimal hyperplasia (IH) in infragenicular supplementary vein cuffs. We aimed to elucidate the consequence of altering geometric configuration in anastomotic hemodynamics in cuff models. A well-validated numerical scheme was used to simulate pulsatile flows in three cuffed anastomotic models with length-to-height ratio (LHR) of 1.4, 2.2 and 3.2, and a St. Mary's boot with LHR of 2.2 at a mean flow rate of 130 mL/min. Characteristic flow patterns and wall shear stress (WSS) distributions were compared. A cohesive vortex is only present in the cuff of LHR = 1.4 and in the boot. The vortex in the cuffs becomes increasingly disorganized with increasing cuff LHR. The area of flow separation at the graft toe, prominent in the cuff of LHR = 3.2, is significantly reduced in the cuff of LHR = 1.4 and eliminated in the boot. All cuffs are characterized by flow separation, flow reversal and a sharp drop in WSS immediately distal to the cuff toe, phenomena not observed in the boot. The cuff configuration, specifically the LHR, is critical in controlling local hemodynamics. A large LHR could lead to reduced cuff performance. The study suggests the benefits of geometric optimization for reconstruction of cuffed anatomoses. |
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Authors:
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F L Xiong; C K Chong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-12 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 37 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-19 Completed Date: 2009-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 301-14 Citation Subset: IM |
Affiliation:
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School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical Blood Flow Velocity / physiology Blood Vessel Prosthesis Computer Simulation* Hemodynamics* Humans Models, Cardiovascular* Pulsatile Flow / physiology* Shear Strength* Tunica Intima / physiopathology* |
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