Document Detail

Numerical simulation of hemodynamic changes during beating-heart surgery: analysis of the effects of cardiac position alteration in an animal model.
MedLine Citation:
PMID:  17209964     Owner:  NLM     Status:  MEDLINE    
Hemodynamic instability, mostly due to vertical lifting of the heart, is usually observed during beating-heart surgical procedures. However, some hemodynamic parameters, such as coronary blood flow, are not routinely measured. A digital computer model of the circulation able to simulate and analyze the effects of heart lifting and the Trendelenburg maneuver, and thus supply detailed hemodynamic information to the clinicians would provide a useful analytical tool. A lumped parameters model of the circulation was applied to both beta-blocked and not beta-blocked pigs. The results confirmed a drop of cardiac output and coronary flow during heart lifting and a rise of both variables after the Trendelenburg maneuver for beta-blocked animals. In not beta-blocked pigs, the analysis was more complex but the model reproduced experimental data and permitted coronary flow to be estimated. These results showed the feasibility of numerical simulation for specific circulatory conditions encountered during beating-heart surgery.
Gianfranco Ferrari; Claudio De Lazzari; Thom L de Kroon; Jan M Elstrodt; Gerhard Rakhorst; Y John Gu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  31     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-09     Completed Date:  2007-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-9     Citation Subset:  IM    
National Council for Research, Institute of Clinical Physiology, Section of Rome, Rome, Italy.
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MeSH Terms
Computer Simulation*
Coronary Artery Bypass, Off-Pump / methods,  veterinary*
Coronary Circulation*
Head-Down Tilt*
Heart / physiopathology*
Models, Animal
Models, Biological*
Ventricular Function, Left
Ventricular Function, Right

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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