| Numerical investigation of the haemodynamics at a patched arterial bypass anastomosis. | |
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MedLine Citation:
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PMID: 12135648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intimal hyperplasia at arterial bypass graft anastomoses is a major factor responsible for graft failure. A revised surgical technique, incorporating a Taylor vein patch into the distal anastomosis of PTFE grafts, results in a decrease in intimal hyperplasia and improved patency rates. Numerical simulations of pulsatile, non-Newtonian blood flow through life-like femorodistal bypass models have been performed to determine whether haemodynamic benefits arise from the modified geometry of the Taylor anastomosis. In a conventional bypass, the distal anastomotic flow exhibited considerable spatial and temporal variations. Steep spatial gradients in the shearing force acted along the floor during systole. The effect of the Taylor geometry was to reduce gradually the momentum of the blood approaching the junction. Thus, flow disturbances were abated, undesirable flow separation at the toe was diminished, and a less adverse floor shear stress distribution prevailed in that case. Intimal thickening should be alleviated at the toe in the Taylor model where separation is reduced, and where the thrombogenic graft surface is replaced with a vein patch. Intimal hyperplasia on the floor may be inhibited in the Taylor model due to more favourable shear stresses. The improved flow through the patched anastomosis should contribute to its enhanced performance. |
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Authors:
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J S Cole; J K Watterson; M J G O'Reilly |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Medical engineering & physics Volume: 24 ISSN: 1350-4533 ISO Abbreviation: Med Eng Phys Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-23 Completed Date: 2002-10-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9422753 Medline TA: Med Eng Phys Country: England |
Other Details:
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Languages: eng Pagination: 393-401 Citation Subset: IM |
Affiliation:
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School of Aeronautical Engineering, The Queen's University of Belfast, Belfast BT9 5AG, Northern Ireland, UK. j.cole@qub.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical
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methods Blood Vessel Prosthesis Computer Simulation Femoral Artery / physiopathology*, surgery* Hemodynamics / physiology Models, Cardiovascular* Polytetrafluoroethylene Regional Blood Flow Reproducibility of Results Sensitivity and Specificity Stress, Mechanical Systole / physiology* Veins / physiopathology*, surgery* |
| Chemical | |
Reg. No./Substance:
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9002-84-0/Polytetrafluoroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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