Document Detail

Numerical abnormalities of chromosome 7 in interphase cell nuclei of breast carcinoma have no impact on immunohistochemically determined EGFR status.
MedLine Citation:
PMID:  10225319     Owner:  NLM     Status:  MEDLINE    
AIM OF STUDY: To investigate the relationship between epidermal growth factor receptor (EGFR) status and numerical aberrations of chromosome 7 in breast carcinomas. DESIGN: In situ hybridization (ISH) of interphase cell nuclei on air-dried fine-needle aspirates (FNAC) from 33 breast carcinomas was evaluated for numerical abnormalities in chromosome 6, 7, 12 and 17. Immunohistochemical staining of EGFR was performed on corresponding histological specimens. RESULTS: 78% of the tumours were aneuploid by ISH. Aneusomy of chromosome 7 was found in 18 cases (60%). EGFR overexpression was observed in 30% of the carcinomas, and seven of nine were aneuploid by ISH. The same percentage of chromosome 7 aneusomy was found in both EGFR-positive and -negative cases. Five of seven EGFR-positive tumours revealed aneusomy of chromosome 7. CONCLUSION: Numerical gain of chromosome 7 is a common finding, occurring in about 60% of breast carcinomas. Most EGFR-positive tumours are aneuploid and show numerical gain of chromosome 7, but abnormal numbers of chromosome 7 have no impact on the EGFR status.
T Sauer; K Beraki; P W Jebsen; O Naess
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  107     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-05-28     Completed Date:  1999-05-28     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  211-6     Citation Subset:  IM    
Department of Pathology, Ullevaal University Hospital, Oslo, Norway.
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MeSH Terms
Breast Neoplasms / genetics*,  metabolism,  pathology
Cell Nucleus
Chromosome Aberrations*
Chromosome Disorders*
Chromosomes, Human, Pair 7*
Receptor, Epidermal Growth Factor / biosynthesis*,  genetics
Reg. No./Substance:
EC, Epidermal Growth Factor

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