| Numerical sex chromosome aberrations and abnormal sex development in horse and sheep. | |
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MedLine Citation:
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PMID: 20110649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gonadal dysgenesis and heterosexual conditions are often associated with sex chromosome abnormalities. In this study we report on 2 cases of abnormal sex development involving numerical sex chromosome aberrations in both horse and sheep. A 17-month-old Standardbred filly was sent to an equine fertility centre as an embryo donor due to its reduced size, being much smaller than a racehorse filly of the same age, which excluded it from an athletic career. External genitalia were clinically normal but manual palpation of the reproductive tract showed the presence of a small underdeveloped uterus and ovaries, as confirmed by ultrasonographic examination. Cytogenetic investigation by CBA-banding revealed an abnormal karyotype with X chromosome monosomy (2n = 63,X). A 18-month-old ewe showed distinct heterosexual traits with presence of a vulva (with enlarged clitoris), well-developed abdominal testes and mammary glands. Internal sex adducts were atrophic as seen after mating. Cytogenetic analysis revealed the presence of XX/XY mosaicism. |
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Authors:
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G P Di Meo; G Neglia; A Perucatti; V Genualdo; A Iannuzzi; D Crocco; D Incarnato; G Romano; P Parma; L Iannuzzi |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-01-27 |
Journal Detail:
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Title: Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation Volume: 3 ISSN: 1661-5433 ISO Abbreviation: Sex Dev Publication Date: 2009 |
Date Detail:
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Created Date: 2010-03-03 Completed Date: 2010-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101316472 Medline TA: Sex Dev Country: Switzerland |
Other Details:
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Languages: eng Pagination: 329-32 Citation Subset: IM |
Affiliation:
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National Research Council, ISPAAM, Laboratory of Animal Cytogenetics and Gene Mapping, Naples, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromosome Banding Female Horses / abnormalities*, genetics* Male Metaphase Sex Chromosome Aberrations* Sex Differentiation Disorders / genetics, veterinary* Sexual Behavior, Animal Sheep / abnormalities*, genetics* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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