Document Detail

Numerical Investigation of Coil Configurations That Provide Ultra-High Packing Density of Saccular Aneurysms.
MedLine Citation:
PMID:  20354576     Owner:  NLM     Status:  Publisher    
BACKGROUND: The long-term outcome of endovascular coiling of cerebral aneurysms is directly related to the packing density at time of treatment. In general, the highest packing density achievable is only about 45% due to the quasi-random distribution of currently available coils within aneurysms. We investigated whether packing densities could be maximized via more ordered coil configurations. METHODS: Three different coil configurations - circular loops, planar spirals, and spherical helices - were investigated. The packing densities achievable in maximally filling the volume of an exemplar human basilar aneurysm with each coil configuration were calculated numerically. Coil packing simulations were also carried out for aneurysms idealized as spheres over diameters ranging from 2 to 30 mm. RESULTS: The packing densities with the loop, spiral, and spherical helix configurations were 82%, 60%, and 73%, respectively, for the human aneurysm model; the numbers of coils required were 693, 34, and 13, respectively. Simulations within idealized aneurysms suggest that aneurysms cannot be packed to more than 91% with coils of constant circular cross-section. The spherical helix configuration provides a constant packing density (coefficient of variation 0.4%) over the range of aneurysm diameters studied as compared to the two other configurations (coefficients of variation 9% and 8%). CONCLUSIONS: Coil configurations that allow for ordered filling of cerebral aneurysms can potentially provide packing densities that are twice those currently achieved. The spherical helix configuration seems to be the most technically feasible and stable configuration of the three coil types investigated.
Chander Sadasivan; Baruch B Lieber
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Publication Detail:
Journal Detail:
Title:  Journal of medical devices     Volume:  3     ISSN:  1932-619X     ISO Abbreviation:  -     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101299321     Medline TA:  J Med Device     Country:  -    
Other Details:
Languages:  ENG     Pagination:  41005     Citation Subset:  -    
Department of Biomedical Engineering, University of Miami, Coral Gables, FL.
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Grant Support
R01 NS045753-05A1//NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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