Document Detail


Numerical Evaluation of Myofiber Orientation and Transmural Contractile Strength on Left Ventricular Function.
MedLine Citation:
PMID:  25367232     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The left ventricle (LV) of the heart is composed of a complex organization of cardiac muscle fibers, which contract to generate force and pump blood into the body. It has been shown that both the orientation and contractile strength of these myofibers vary across the ventricular wall. The hypothesis of the current study is that the transmural distributions of myofiber orientation and contractile strength interdependently impact LV pump function. In order to quantify these interactions a finite element model of the LV was generated, which incorporated transmural variations. The influence of myofiber orientation and contractile strength on the Starling relationship and the end-systolic apex twist of the LV was assessed. The results suggest that reductions in contractile strength within a specific transmural layer amplified the effects of altered myofiber orientation in the same layer, causing greater changes in stroke volume. Furthermore, when the epicardial myofibers contracted the strongest, the twist of the LV apex was greatest, regardless of myofiber orientation. These results demonstrate the important role of transmural distribution of myocardial contractile strength and its interplay with myofiber orientation. The coupling between these two physiologic parameters could play a critical role in the progression of heart failure.
Authors:
Xiaoyan Zhang; Premi Haynes; Kenneth S Campbell; Jonathan F Wenk
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-1
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  -     ISSN:  1528-8951     ISO Abbreviation:  J Biomech Eng     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-4     Completed Date:  -     Revised Date:  2014-11-5    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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