Document Detail


Numbers of colony-forming progenitors in patients with systemic mastocytosis: potential diagnostic implications and comparison with myeloproliferative disorders.
MedLine Citation:
PMID:  12814399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: An increase in colony-forming progenitor cells (CFU) is typically seen in myeloproliferative disorders (MPD). Systemic mastocytosis (SM) is a haemopoietic neoplasm involving myeloid progenitors similar to MPD. In the present study, we measured the levels of peripheral blood (pb) and bone marrow (bm) CFU in patients with different categories of SM, and compared them with those obtained in MPD patients and healthy controls. MATERIALS AND METHODS: Numbers of CFU (CFU-GM, BFU-E, CFU-GEMM) were measured in a colony assay in 25 patients with SM [indolent SM (ISM), n = 15; smouldering SM (SSM), n = 3; SM with an associated haematologic clonal non-mast cell lineage disease (SM-AHNMD), n = 5; aggressive SM (ASM), n = 1; mast cell leukaemia (MCL), n = 1] and 37 with MPD [chronic myeloid leukaemia (CML), n = 10; polycythemia vera (PV), n = 8; essential thrombocytosis (ET), n = 9; idiopathic myelofibrosis (IMF), n = 10]. RESULTS: In the patients with MPD, elevated numbers of pb CFU were detected in all groups when compared with healthy controls (P < 0.05). In most of the patients with ISM, circulating CFU levels (CFU-GM, BFU-E, and CFU-GEMM) were within the normal range. In SSM, pb CFU-GM levels were normal in two patients, and elevated in a third patient. In the "SM-AHNMD-group", CFU levels were found to reflect the nature of the AHNMD: in SM with concomitant acute myeloid leukaemia (SM-AML, n = 2), the levels of CFU were low or undetectable, whereas in SM with chronic myelomonocytic leukaemia (SM-CMML, n = 2), elevated numbers of pb CFU-GM were found. CONCLUSION: The numbers of CFU are normal in patients with ISM, but elevated in some patients with SSM and SM-CMML. An elevated CFU level in SM should raise the suspicion of an associated MPD (CMML) or smouldering SM, a novel SM-subtype that shares several features with MPD and sometimes progresses to an overt SM-MPD.
Authors:
J-H Jordan; E Jäger; W R Sperr; I Schwarzinger; M Födinger; R Fritsche-Polanz; L Ohler; K Geissler; P Valent
Related Documents :
11157029 - Troxacitabine, a novel dioxolane nucleoside analog, has activity in patients with advan...
3465429 - Granulocytic sarcoma in nonleukemic patients.
22071459 - Primary restoration of elbow flexion in adult post-traumatic plexopathy patients.
292969 - Bone marrow karyotypes of children with nonlymphocytic leukemia.
9753069 - The influence of hla-matched sibling donor availability on treatment outcome for patien...
3312839 - The ucla experience with type i interferons in hairy cell leukemia.
1475629 - Normal inflammatory bowel disease mucosa conceals alterations in natural killer cell ac...
16182009 - Hyperacute measurement of brain-tissue oxygen, carbon dioxide, ph, and intracranial pre...
20058509 - Does time delay between the primary cardiac arrest and pci affect outcome?
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  33     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-19     Completed Date:  2003-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  611-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Bone Marrow Cells / pathology*
Cell Count / methods
Colony-Forming Units Assay
Diagnosis, Differential
Female
Humans
Male
Mast Cells / pathology
Mastocytosis / blood*,  diagnosis
Middle Aged
Myeloproliferative Disorders / blood,  diagnosis*
Stem Cells / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Low mast cell density in the human duodenal mucosa from chronic inflammatory duodenal bowel disorder...
Next Document:  Recovery of T-cell subsets after antiretroviral therapy in HIV-infected children.