Document Detail

Number of ovarian follicles in human fetuses with the 45,X karyotype.
MedLine Citation:
PMID:  15066472     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the numbers of ovarian follicles during fetal life in the gonads of human female fetuses with the 45,X karyotype (Turner syndrome, TS) and to compare them with those from age-matched 46,XX fetuses. DESIGN: Retrospective study. SETTING: An academic hospital. PATIENT(S): Ovarian samples from TS fetuses (aged 17-37 weeks), mainly obtained after induced abortion, and ovaries from eight control fetuses (matching gestational ages). INTERVENTION(S): Embedded blocks of ovaries were collected from anatomy-pathology departments of three university hospitals and were sectioned and stained with hematoxylin-eosin. MAIN OUTCOME MEASURE(S): Observation of primordial and growing follicles. RESULT(S): In the fetal ovaries of controls, numerous oogonia were observed at 18 weeks. Primordial follicles were present in all ovaries from 20 weeks' gestation onward, whereas preantral and antral follicles were observed from 26 weeks onwards. In ovaries from 45,X TS fetuses, oogonia were observed in some ovaries, but no primordial, preantral, or antral follicles were found, even in ovaries from the third trimester of gestation. CONCLUSION(S): Follicle formation and growth are severely reduced in ovaries from aborted 45,X TS fetuses.
Karine Reynaud; Rita Cortvrindt; Franciska Verlinde; Jean De Schepper; Claire Bourgain; Johan Smitz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  81     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-06     Completed Date:  2004-05-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1112-9     Citation Subset:  IM    
Academisch Ziekenhuis van de Vrije Universiteit Brussel, Brussels, Belgium.
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MeSH Terms
Abortion, Induced
Case-Control Studies
Embryo, Mammalian / pathology
Gestational Age
Oogonia / pathology
Ovarian Follicle / embryology*
Turner Syndrome / embryology*,  genetics

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