Document Detail

Number of glomeruli is increased in the kidney of transgenic mice expressing the truncated type II activin receptor.
MedLine Citation:
PMID:  10679224     Owner:  NLM     Status:  MEDLINE    
Histological analyses of the kidney were performed in transgenic mice expressing the truncated type II activin receptor. In these mice, signaling through the activin receptor was attenuated. Size and wet weight of the kidneys were identical to those of normal mice. Histologically, the number of glomeruli was approximately 180% of that in normal mice. The sizes and shapes of the glomeruli were variable, but many of them were smaller than those in normal mice. Morphometrically, the total glomerular area was 130% of that of the normal mice. Abnormality of the epithelia in Bowman's capsule was observed and the number of tubular epithelial cells was increased in the transgenic mice. The serum levels of blood urea nitrogen, creatinine, and creatinine clearance were identical to those in normal mice. These results suggest that the action of activin or related ligands is critical for determination of the nephron number.
A Maeshima; S Shiozaki; T Tajima; Y Nakazato; T Naruse; I Kojima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  268     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-10     Completed Date:  2000-03-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  445-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371-8511, Japan.
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MeSH Terms
Activin Receptors, Type II
Cell Count
Gene Deletion
Glomerular Mesangium / abnormalities*,  embryology
Mice, Inbred C57BL
Mice, Transgenic
Receptors, Growth Factor / biosynthesis,  genetics,  physiology*
Reg. No./Substance:
0/Receptors, Growth Factor; EC Receptors, Type II

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