| Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition study. | |
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MedLine Citation:
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PMID: 19196642 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Few studies have examined the risk of multiple or high doses of combined central nervous system (CNS) medication use for recurrent falls in the elderly. The study objective was to evaluate whether multiple- or high-dose CNS medication use in older adults was associated with a higher risk of recurrent (>or=2) falls. METHODS: This longitudinal cohort study included 3,055 participants from the Health, Aging and Body Composition study who were well functioning at baseline. CNS medication use (benzodiazepine and opioid receptor agonists, antipsychotics, antidepressants) was determined annually (except Year 4) during in-person interviews. The number and summated standard daily doses (SDDs; low, medium, and high) of CNS medications were computed. Falls 1 year later were ascertained annually for 5 years. RESULTS: For a period of 5 years, as many as 24.1% of CNS medication users took 2+ agents annually, whereas as no more than 18.9% of CNS medication users took high doses annually (3+ SDDs). Yearly, as many as 9.7% of participants reported recurrent falls. Multivariable Generalized Estimating Equation analyses showed that multiple CNS medication users compared with never users had an increased risk of sustaining 2+ falls (adjusted odds ratio [OR] 1.95; 95% confidence interval [CI] 1.35-2.81). Those taking high (3+) CNS SDDs also exhibited an increased risk of 2+ falls (adjusted OR 2.89; 95% CI 1.96-4.25). CONCLUSIONS: Higher total daily doses of CNS medications were associated with recurrent falls. Further studies are needed to determine the impact of reducing the number of CNS medications and/or dosage on recurrent falls. |
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Authors:
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Joseph T Hanlon; Robert M Boudreau; Yazan F Roumani; Anne B Newman; Christine M Ruby; Rollin M Wright; Sarah N Hilmer; Ronald I Shorr; Douglas C Bauer; Eleanor M Simonsick; Stephanie A Studenski |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural Date: 2009-02-04 |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 64 ISSN: 1758-535X ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-18 Completed Date: 2009-04-21 Revised Date: 2011-05-04 |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 492-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Geriatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA. hanlonj@dom.pitt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Accidental Falls
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prevention & control,
statistics & numerical data* Aged Aging / drug effects*, physiology Antidepressive Agents / adverse effects, therapeutic use Antipsychotic Agents / adverse effects, therapeutic use Benzodiazepines / adverse effects, therapeutic use Body Composition Central Nervous System Agents / adverse effects*, therapeutic use Cohort Studies Confidence Intervals Dose-Response Relationship, Drug Drug Utilization Female Geriatric Assessment Health Status Humans Incidence Longitudinal Studies Male Odds Ratio Prognosis Recurrence Residence Characteristics Risk Assessment |
| Grant Support | |
ID/Acronym/Agency:
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N01 AG062101/AG/NIA NIH HHS; N01-AG-6-2101/AG/NIA NIH HHS; N01-AG-6-2103/AG/NIA NIH HHS; N01-AG-6-2106/AG/NIA NIH HHS; P30 AG024827-05/AG/NIA NIH HHS; P30AG024827/AG/NIA NIH HHS; R01 AG027017-03/AG/NIA NIH HHS; R01AG027017/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Antipsychotic Agents; 0/Central Nervous System Agents; 12794-10-4/Benzodiazepines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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