| Null activity of selenium and vitamin e as cancer chemopreventive agents in the rat prostate. | |
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MedLine Citation:
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PMID: 20145190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the potential efficacy of selenium and vitamin E as inhibitors of prostate carcinogenesis, four chemoprevention studies using a common protocol were done in a rat model of androgen-dependent prostate cancer. After stimulation of prostate epithelial cell proliferation by a sequential regimen of cyproterone acetate followed by testosterone propionate, male Wistar-Unilever rats received a single i.v. injection of N-methyl-N-nitrosourea (MNU) followed by chronic androgen stimulation via subcutaneous implantation of testosterone pellets. At 1 week post-MNU, groups of carcinogen-treated rats (39-44/group) were fed either a basal diet or a basal diet supplemented with l-selenomethionine (3 or 1.5 mg/kg diet; study 1), dl-alpha-tocopherol (vitamin E, 4,000 or 2,000 mg/kg diet; study 2), l-selenomethionine + vitamin E (3 + 2,000 mg/kg diet or 3 + 500 mg/kg diet; study 3), or selenized yeast (target selenium levels of 9 or 3 mg/kg diet; study 4). Each chemoprevention study was terminated at 13 months post-MNU, and prostate cancer incidence was determined by histopathologic evaluation. No statistically significant reductions in prostate cancer incidence were identified in any group receiving dietary supplementation with selenium and/or vitamin E. These data do not support the hypotheses that selenium and vitamin E are potent cancer chemopreventive agents in the prostate, and when considered with the recent clinical data reported in the Selenium and Vitamin E Cancer Prevention Trial (SELECT), show the predictive nature of this animal model for human prostate cancer chemoprevention. |
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Authors:
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David L McCormick; K V N Rao; William D Johnson; Maarten C Bosland; Ronald A Lubet; Vernon E Steele |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-02-09 |
Journal Detail:
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Title: Cancer prevention research (Philadelphia, Pa.) Volume: 3 ISSN: 1940-6215 ISO Abbreviation: Cancer Prev Res (Phila) Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-06-08 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 101479409 Medline TA: Cancer Prev Res (Phila) Country: United States |
Other Details:
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Languages: eng Pagination: 381-92 Citation Subset: IM |
Affiliation:
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Life Sciences Research, IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA. dmccormick@iitri.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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chemically induced,
pathology,
prevention & control* Alkylating Agents / toxicity Androgens / administration & dosage Animals Antioxidants / pharmacology Cyproterone Acetate / therapeutic use Disease Models, Animal Drug Therapy, Combination Male Methylnitrosourea / toxicity Neoplasms, Hormone-Dependent / chemically induced, pathology, prevention & control* Prostatic Neoplasms / chemically induced, pathology, prevention & control* Rats Rats, Wistar Selenium Compounds / therapeutic use* Selenomethionine / administration & dosage* Testosterone / administration & dosage Vitamin E / therapeutic use* alpha-Tocopherol / therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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N01 CN065120/CN/NCI NIH HHS; N01 CN095113/CN/NCI NIH HHS; N01 CN35566-02/CN/NCI NIH HHS; N01-CN-35566-02/CN/NCI NIH HHS; N01-CN-65120/CN/NCI NIH HHS; N01-CN-95113/CN/NCI NIH HHS; P30-CA-16087/CA/NCI NIH HHS; P30-ES-00260/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Alkylating Agents; 0/Androgens; 0/Antioxidants; 0/Selenium Compounds; 1406-18-4/Vitamin E; 1464-42-2/Selenomethionine; 427-51-0/Cyproterone Acetate; 58-22-0/Testosterone; 59-02-9/alpha-Tocopherol; 684-93-5/Methylnitrosourea |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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