| Nud1p, the yeast homolog of Centriolin, regulates spindle pole body inheritance in meiosis. | |
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MedLine Citation:
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PMID: 16888627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nud1p, a protein homologous to the mammalian centrosome and midbody component Centriolin, is a component of the budding yeast spindle pole body (SPB), with roles in anchorage of microtubules and regulation of the mitotic exit network during vegetative growth. Here we analyze the function of Nud1p during yeast meiosis. We find that a nud1-2 temperature-sensitive mutant has two meiosis-related defects that reflect genetically distinct functions of Nud1p. First, the mutation affects spore formation due to its late function during spore maturation. Second, and most important, the mutant loses its ability to distinguish between the ages of the four spindle pole bodies, which normally determine which SPB would be preferentially included in the mature spores. This affects the regulation of genome inheritance in starved meiotic cells and leads to the formation of random dyads instead of non-sister dyads under these conditions. Both functions of Nud1p are connected to the ability of Spc72p to bind to the outer plaque and half-bridge (via Kar1p) of the SPB. |
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Authors:
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Oren Gordon; Christof Taxis; Philipp J Keller; Aleksander Benjak; Ernst H K Stelzer; Giora Simchen; Michael Knop |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-08-03 |
Journal Detail:
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Title: The EMBO journal Volume: 25 ISSN: 0261-4189 ISO Abbreviation: EMBO J. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-30 Completed Date: 2006-10-20 Revised Date: 2011-10-13 |
Medline Journal Info:
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Nlm Unique ID: 8208664 Medline TA: EMBO J Country: England |
Other Details:
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Languages: eng Pagination: 3856-68 Citation Subset: IM |
Affiliation:
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Department of Genetics, The Hebrew University of Jerusalem, Jerusalem, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle Proteins
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genetics Deoxyribonucleases / genetics, physiology* Genome, Fungal Humans Meiosis / physiology* Microtubule-Associated Proteins / metabolism Mitotic Spindle Apparatus / physiology* Mutation Nuclear Proteins / metabolism Protein Binding Saccharomyces cerevisiae / metabolism, physiology* Saccharomyces cerevisiae Proteins / genetics, metabolism, physiology* Spores, Fungal / physiology* tRNA Methyltransferases |
| Chemical | |
Reg. No./Substance:
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0/CNTRL protein, human; 0/Cell Cycle Proteins; 0/KAR1 protein, S cerevisiae; 0/Microtubule-Associated Proteins; 0/Nuclear Proteins; 0/SPC72 protein, S cerevisiae; 0/Saccharomyces cerevisiae Proteins; EC 2.1.1.-/tRNA Methyltransferases; EC 3.1.-/Deoxyribonucleases; EC 3.1.-/TRM2 protein, S cerevisiae |
| Comments/Corrections | |
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