Document Detail


Nucleus tractus solitarius lesions elevate pulmonary arterial pressure and lymph flow.
MedLine Citation:
PMID:  4026226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of lesions of the nucleus tractus solitarius (NTS) on pulmonary vascular pressure and pulmonary lymph flow were investigated in 6 halothane-anesthetized sheep. After lesions of the NTS were created using bilateral thermocoagulation, pulmonary artery pressure rose to 150% of baseline and remained elevated for the 3-hour duration of the experiment. Systemic and left atrial pressures did not change. Pulmonary lymph flow doubled within 2 hours; the lymph-plasma protein ratio was unchanged from baseline. Sham NTS lesions and lesions lateral to NTS produced no changes. These experiments demonstrate that lesions of the central nervous system can alter pulmonary vascular pressures and transcapillary fluid flux independently of effects upon the systemic circulation. These findings may have relevance for the understanding of neurogenic pulmonary edema in humans.
Authors:
T M Darragh; R P Simon
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of neurology     Volume:  17     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-08-26     Completed Date:  1985-08-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  565-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Blood Vessels / innervation
Female
Lung / blood supply,  physiopathology*
Lymphatic System / physiopathology*
Medulla Oblongata / injuries*,  pathology
Pulmonary Artery
Pulmonary Edema / etiology*,  pathology
Sheep
Grant Support
ID/Acronym/Agency:
5 K07 NS 00437/NS/NINDS NIH HHS; GM 18470/GM/NIGMS NIH HHS; HL 25816/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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