Document Detail

Nucleus accumbens acetylcholine and food intake: decreased muscarinic tone reduces feeding but not food-seeking.
MedLine Citation:
PMID:  19041901     Owner:  NLM     Status:  MEDLINE    
Separate groups of food-deprived rats were given 2h access to food after receiving bilateral nucleus accumbens infusions of the muscarinic antagonist scopolamine methyl bromide (at 0, 1.0, and 10.0 microg/side), the M2-preferring agonist oxotremorine sesquifumarate (Oxo-S; at 0, 1.0, or 10.0 microg/side) or the M2 antagonist AFDX-116 (at 0, 0.2, or 1.0 microg/side). Injections of scopolamine or Oxo-S, but not AFDX-116, reduced food consumption across the 2h. These experiments confirm a critical role for Acb acetylcholine in promoting food ingestion, and suggest that decreased acetylcholine tone at post-synaptic muscarinic receptors disrupts normal consummatory behavior.
Wayne E Pratt; Kaitlin Blackstone
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-11
Journal Detail:
Title:  Behavioural brain research     Volume:  198     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  252-7     Citation Subset:  IM    
Department of Psychology, Wake Forest University, Winston-Salem, NC, USA.
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MeSH Terms
Acetylcholine / physiology*
Dose-Response Relationship, Drug
Eating / drug effects*,  physiology
Feeding Behavior / drug effects*,  physiology
Muscarinic Agonists / administration & dosage,  pharmacology
Muscarinic Antagonists / administration & dosage,  pharmacology
N-Methylscopolamine / administration & dosage,  pharmacology
Nucleus Accumbens / drug effects,  physiology*
Oxotremorine / administration & dosage,  analogs & derivatives,  pharmacology
Parasympatholytics / administration & dosage,  pharmacology
Pirenzepine / administration & dosage,  analogs & derivatives,  pharmacology
Rats, Sprague-Dawley
Receptors, Muscarinic / drug effects,  physiology*
Reg. No./Substance:
0/Muscarinic Agonists; 0/Muscarinic Antagonists; 0/Parasympatholytics; 0/Receptors, Muscarinic; 102394-31-0/otenzepad; 13265-10-6/N-Methylscopolamine; 17360-35-9/oxotremorine sesquifumarate; 28797-61-7/Pirenzepine; 51-84-3/Acetylcholine; 70-22-4/Oxotremorine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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