| Nucleotide sequence of a mouse Tcp-1 pseudogene: a nucleotide record for a t complex gene carried by an ancestor of the mouse. | |
MedLine Citation:
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PMID: 1543916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have isolated clones of a processed pseudogene of mouse t complex polypeptide 1 (Tcp-1) and determined the nucleotide sequence of the pseudogene. The pseudogene was 1363 bp long and had no intron. The Tcp-1 pseudogene had 88.4% or 88.3% nucleotide identity to the mouse Tcp-1 cDNA of wild-type (Tcp-1b) or t haplotype (Tcp-1a), and 87.5% identity to the rat Tcp-1 cDNA. On 12 nucleotide positions where the open reading frames (ORFs) of mouse Tcp-1b and Tcp-1a cDNAs have bp substitutions, the Tcp-1 pseudogene had 6 bp identical to Tcp-1b, 5 bp identical to Tcp-1a and 1 bp not identical to neither. On ten amino acid positions where TCP-1B and TCP-1A polypeptides have substitutions, deduced amino acids of the Tcp-1 pseudogene had four amino acids identical to TCP-1B, five amino acids identical to TCP-1A and one amino acid identical to neither. These results suggest that the ancestral mouse Tcp-1 gene would have had no significant difference between the resemblance to Tcp-1b and that to Tcp-1a before they were diverged and that amino acids of TCP-1B and TCP-1A would have been substituted in similar high rates. |
Authors:
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H Kubota; T Morita; Y Satta; M Nozaki; A Matsushiro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mammalian genome : official journal of the International Mammalian Genome Society Volume: 2 ISSN: 0938-8990 ISO Abbreviation: Mamm. Genome Publication Date: 1992 |
Date Detail:
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Created Date: 1992-04-16 Completed Date: 1992-04-16 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9100916 Medline TA: Mamm Genome Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 246-51 Citation Subset: IM |
Affiliation:
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Department of Microbial Genetics, Osaka University, Japan. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/D00851 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Blotting, Southern Cloning, Molecular DNA Evolution Humans Intracellular Signaling Peptides and Proteins* Mice Microtubule-Associated Proteins* Molecular Sequence Data Nuclear Proteins / genetics* Phylogeny Pseudogenes* Restriction Mapping Sequence Homology, Nucleic Acid Testicular Hormones / genetics* t-Complex Genome Region |
| Chemical | |
Reg. No./Substance:
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0/Intracellular Signaling Peptides and Proteins; 0/Microtubule-Associated Proteins; 0/Nuclear Proteins; 0/PPP1R11 protein, human; 0/Testicular Hormones; 9007-49-2/DNA |
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