Document Detail

Nucleotide sequence of a mouse Tcp-1 pseudogene: a nucleotide record for a t complex gene carried by an ancestor of the mouse.
MedLine Citation:
PMID:  1543916     Owner:  NLM     Status:  MEDLINE    
We have isolated clones of a processed pseudogene of mouse t complex polypeptide 1 (Tcp-1) and determined the nucleotide sequence of the pseudogene. The pseudogene was 1363 bp long and had no intron. The Tcp-1 pseudogene had 88.4% or 88.3% nucleotide identity to the mouse Tcp-1 cDNA of wild-type (Tcp-1b) or t haplotype (Tcp-1a), and 87.5% identity to the rat Tcp-1 cDNA. On 12 nucleotide positions where the open reading frames (ORFs) of mouse Tcp-1b and Tcp-1a cDNAs have bp substitutions, the Tcp-1 pseudogene had 6 bp identical to Tcp-1b, 5 bp identical to Tcp-1a and 1 bp not identical to neither. On ten amino acid positions where TCP-1B and TCP-1A polypeptides have substitutions, deduced amino acids of the Tcp-1 pseudogene had four amino acids identical to TCP-1B, five amino acids identical to TCP-1A and one amino acid identical to neither. These results suggest that the ancestral mouse Tcp-1 gene would have had no significant difference between the resemblance to Tcp-1b and that to Tcp-1a before they were diverged and that amino acids of TCP-1B and TCP-1A would have been substituted in similar high rates.
H Kubota; T Morita; Y Satta; M Nozaki; A Matsushiro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mammalian genome : official journal of the International Mammalian Genome Society     Volume:  2     ISSN:  0938-8990     ISO Abbreviation:  Mamm. Genome     Publication Date:  1992  
Date Detail:
Created Date:  1992-04-16     Completed Date:  1992-04-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9100916     Medline TA:  Mamm Genome     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  246-51     Citation Subset:  IM    
Department of Microbial Genetics, Osaka University, Japan.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Blotting, Southern
Cloning, Molecular
Intracellular Signaling Peptides and Proteins*
Microtubule-Associated Proteins*
Molecular Sequence Data
Nuclear Proteins / genetics*
Restriction Mapping
Sequence Homology, Nucleic Acid
Testicular Hormones / genetics*
t-Complex Genome Region
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/Microtubule-Associated Proteins; 0/Nuclear Proteins; 0/PPP1R11 protein, human; 0/Testicular Hormones; 9007-49-2/DNA

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