Document Detail


Nucleotide sequence of a human cytomegalovirus DNA fragment encoding a 67-kilodalton phosphorylated viral protein.
MedLine Citation:
PMID:  2993668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previously, we demonstrated that a DNA fragment from the L-unique region at 0.37 to 0.39 map units of human cytomegalovirus DNA codes for a 67-kilodalton phosphorylated tegument protein. (Davis et al., J. Virol. 52:129-135, 1984). We have determined the nucleotide sequence of this DNA, transcription initiation and termination, and putative promoter region. We also compared the properties of the protein product predicted from the DNA sequence with the properties of the protein isolated by immunoabsorbent column chromatography. This viral structural protein may have important functions, such as protein kinase activity, DNA binding, and possible transcriptional activation of immediate-early genes.
Authors:
M G Davis; E S Huang
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of virology     Volume:  56     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-10-22     Completed Date:  1985-10-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7-11     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M11911
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Base Sequence
Codon
Cytomegalovirus / genetics*
DNA / genetics
DNA, Viral / genetics*
DNA-Binding Proteins / genetics
Genes
Genes, Viral
Molecular Weight
Phosphoproteins / genetics
RNA, Messenger / genetics
Repetitive Sequences, Nucleic Acid
Viral Proteins / genetics*
Grant Support
ID/Acronym/Agency:
AI15036/AI/NIAID NIH HHS; CA19014/CA/NCI NIH HHS; CA21773/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Codon; 0/DNA, Viral; 0/DNA-Binding Proteins; 0/Phosphoproteins; 0/RNA, Messenger; 0/Viral Proteins; 9007-49-2/DNA
Comments/Corrections

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