| Nucleotide and oligonucleotide derivatives as enzyme and nucleic acid targeted irreversible inhibitors. Chemical aspects. | |
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MedLine Citation:
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PMID: 3915185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reactive derivatives of nucleic acid components are the promising affinity reagents for specific modification of nucleic acids and nucleic acid-related proteins. Reactive ATP derivatives synthesized using the simple method described in the present chapter are potent specific inhibitors of various enzymes interacting with ATP. Reactive oligonucleotide derivatives bind to complementary nucleotide sequences in nucleic acids and modify them in the neighborhood of the binding area. Modification with these derivatives (complementary addressed modification) may become an efficient approach for specific arrest of certain cellular biopolymer biosynthesis and for site-directed mutagenesis. In this chapter, synthesis of alkylating oligonucleotide derivatives is described in detail and the results of their application for modification of nucleic acids in vitro are summarized. The results allow one to think about future biochemical and biomedical applications of complementary addressed modification. |
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Authors:
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D G Knorre; V V Vlassov; V F Zarytova; G G Karpova |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Advances in enzyme regulation Volume: 24 ISSN: 0065-2571 ISO Abbreviation: Adv. Enzyme Regul. Publication Date: 1985 |
Date Detail:
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Created Date: 1986-06-27 Completed Date: 1986-06-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0044263 Medline TA: Adv Enzyme Regul Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 277-99 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkylation Benzaldehydes Chemical Phenomena Chemistry Mustard Compounds Nucleic Acids Oligonucleotides* / chemical synthesis Phosphates |
| Chemical | |
Reg. No./Substance:
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0/Benzaldehydes; 0/Mustard Compounds; 0/Nucleic Acids; 0/Oligonucleotides; 0/Phosphates; 36665-43-7/4(N)-(2-chloroethyl-N-methylamino)benzylamine; 94-31-5/4-((2-chloroethyl)methylamino)benzaldehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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