| Nucleotide exchange factors for Hsp70s are required for [URE3] prion propagation in Saccharomyces cerevisiae. | |
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MedLine Citation:
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PMID: 17392510 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The [URE3] and [PSI(+)] prions are infectious amyloid forms of Ure2p and Sup35p. Several chaperones influence prion propagation: Hsp104p overproduction destabilizes [PSI(+)], whereas [URE3] is sensitive to excess of Ssa1p or Ydj1p. Here, we show that overproduction of the chaperone, Sse1p, can efficiently cure [URE3]. Sse1p and Fes1p are nucleotide exchange factors for Ssa1p. Interestingly, deletion of either SSE1 or FES1 completely blocked [URE3] propagation. In addition, deletion of SSE1 also interfered with [PSI(+)] propagation. |
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Authors:
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Dmitry Kryndushkin; Reed B Wickner |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2007-03-28 |
Journal Detail:
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Title: Molecular biology of the cell Volume: 18 ISSN: 1059-1524 ISO Abbreviation: Mol. Biol. Cell Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-25 Completed Date: 2007-10-31 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9201390 Medline TA: Mol Biol Cell Country: United States |
Other Details:
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Languages: eng Pagination: 2149-54 Citation Subset: IM |
Affiliation:
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Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0830, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphatases
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genetics,
metabolism Glutathione Peroxidase Guanine Nucleotide Exchange Factors / genetics, metabolism* HSP110 Heat-Shock Proteins / genetics, metabolism* HSP40 Heat-Shock Proteins / genetics, metabolism HSP70 Heat-Shock Proteins / genetics, metabolism* Intracellular Signaling Peptides and Proteins / genetics, metabolism Point Mutation Prions / genetics, metabolism* Saccharomyces cerevisiae / cytology, genetics, metabolism* Saccharomyces cerevisiae Proteins / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/FES1 protein, S cerevisiae; 0/Guanine Nucleotide Exchange Factors; 0/HSP110 Heat-Shock Proteins; 0/HSP40 Heat-Shock Proteins; 0/HSP70 Heat-Shock Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Prions; 0/SSE1 protein, S cerevisiae; 0/Saccharomyces cerevisiae Proteins; 139874-78-5/YDJ1 protein, S cerevisiae; EC 1.11.1.9/Glutathione Peroxidase; EC 1.11.1.9/URE2 protein, S cerevisiae; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.3/SSA1 protein, S cerevisiae |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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