Document Detail


Nucleostemin: a multiplex regulator of cell-cycle progression.
MedLine Citation:
PMID:  18951797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nucleostemin (NS) is a protein concentrated in the nucleolus of most stem cells and also in many tumor cells, which has been implicated in cell-cycle progression owing to its ability to modulate p53. Depletion of NS causes G(1) cell-cycle arrest, but its overexpression does so as well. Recently, this paradox has been clarified. NS overexpression causes a sequestration of murine double minute 2 (MDM2), preventing the destruction of p53. A recent study has demonstrated that loss of NS promotes the interaction of L5 and L11 ribosomal proteins with MDM2 and, thus, also prevents p53 degradation. This new finding expands our understanding of the multiple modes of NS action and reinforces the concept that the nucleolus has key roles in cell-cycle progression.
Authors:
Hanhui Ma; Thoru Pederson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-10-23
Journal Detail:
Title:  Trends in cell biology     Volume:  18     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-28     Completed Date:  2009-08-24     Revised Date:  2010-09-23    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  575-9     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01609, USA. hanhui.ma@umassmed.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Carrier Proteins / genetics,  metabolism*
Cell Cycle*
Humans
Nuclear Proteins / genetics,  metabolism*
Proto-Oncogene Proteins c-mdm2 / metabolism
Ribosomal Proteins / metabolism
Tumor Suppressor Protein p53 / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/GNL3 protein, human; 0/Nuclear Proteins; 0/Ribosomal Proteins; 0/Tumor Suppressor Protein p53; EC 6.3.2.19/Proto-Oncogene Proteins c-mdm2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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