Document Detail

Nucleostemin affects the proliferation but not differentiation of oral squamous cell carcinoma cells.
MedLine Citation:
PMID:  21443540     Owner:  NLM     Status:  Publisher    
Nucleostemin (NS) has been reported essential for stem and cancer cell proliferation. To investigate significance of NS in oral squamous cell carcinomas (OSCCs), we examined NS expression in neoplastic tissue of the tongue and in OSCC cell lines. NS expression in the histological samples showed positive correlation with Ki-67 expression. Further, NS expression was associated with cellular proliferation in OSCC cell lines using small interfering RNA (siRNA), which up-regulated p27, a cyclin-dependent kinase inhibitor. Regarding to OSCC differentiation, NS expression did not influence cornification and oral epithelial differentiation markers such as involucrin (Invo) and cytokeratin19 (CK19). Thus, NS is widely expressed in normal and neoplastic oral epithelial tissues, and is likely a marker of proliferation.
Ryoji Yoshida; Tetsuhiro Fujimoto; Shinji Kudoh; Masashi Nagata; Hideki Nakayama; Masanori Shinohara; Takaaki Ito
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-28
Journal Detail:
Title:  Cancer science     Volume:  -     ISSN:  1349-7006     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101168776     Medline TA:  Cancer Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Japanese Cancer Association.
Departments of Pathology and Experimental Medicine Oral and Maxillofacial Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
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