| Nucleosome dynamics between tension-induced states. | |
| | |
MedLine Citation:
|
PMID: 22677376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We studied the dynamical behavior of a mononucleosome under tension using a theoretical model that takes into account the nucleosomal geometry, DNA elasticity, nonspecific DNA-protein binding, and effective repulsion between the two DNA turns. Using a dynamical Monte-Carlo simulation algorithm, we demonstrate that this model shows a behavior that for an appropriate set of parameters is in quantitative agreement with data from micromanipulation experiments on individual nucleosomes. All of the parameters of the model follow from the data obtained from two types of pulling experiments, namely, constant force and constant loading rate ensembles. |
| | |
Authors:
|
Laleh Mollazadeh-Beidokhti; Farshid Mohammad-Rafiee; Helmut Schiessel |
Related Documents
:
|
18641056 - Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in... 19903746 - Review of pathological hallmarks of schizophrenia: comparison of genetic models with pa... 16690346 - Recent developments and future prospects in insect pest control in transgenic crops. 12921416 - Reading nonwords aloud: results requiring change in the dual route cascaded model. 19423386 - What does the ratio of injected current to electrode area tell us about current density... 18641056 - Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-05-15 |
Journal Detail:
|
Title: Biophysical journal Volume: 102 ISSN: 1542-0086 ISO Abbreviation: Biophys. J. Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-06-08 Completed Date: 2012-10-04 Revised Date: 2013-05-16 |
Medline Journal Info:
|
Nlm Unique ID: 0370626 Medline TA: Biophys J Country: United States |
Other Details:
|
Languages: eng Pagination: 2235-40 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Biophysical Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Biological Sciences, Institute for Advanced Studies in Basic Sciences, Zanjan, Iran. laleh@iasbs.ac.ir |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Binding Sites DNA / chemistry, metabolism Models, Biological* Nucleic Acid Conformation Nucleosomes / chemistry, metabolism* Stress, Mechanical* Thermodynamics Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Nucleosomes; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: How do parents find out about the ketogenic diet?
Next Document: Mapping three-dimensional stress and strain fields within a soft hydrogel using a fluorescence micro...