Document Detail

Nucleosome dynamics between tension-induced states.
MedLine Citation:
PMID:  22677376     Owner:  NLM     Status:  MEDLINE    
We studied the dynamical behavior of a mononucleosome under tension using a theoretical model that takes into account the nucleosomal geometry, DNA elasticity, nonspecific DNA-protein binding, and effective repulsion between the two DNA turns. Using a dynamical Monte-Carlo simulation algorithm, we demonstrate that this model shows a behavior that for an appropriate set of parameters is in quantitative agreement with data from micromanipulation experiments on individual nucleosomes. All of the parameters of the model follow from the data obtained from two types of pulling experiments, namely, constant force and constant loading rate ensembles.
Laleh Mollazadeh-Beidokhti; Farshid Mohammad-Rafiee; Helmut Schiessel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-15
Journal Detail:
Title:  Biophysical journal     Volume:  102     ISSN:  1542-0086     ISO Abbreviation:  Biophys. J.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-08     Completed Date:  2012-10-04     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2235-40     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Biophysical Society. Published by Elsevier Inc. All rights reserved.
Department of Biological Sciences, Institute for Advanced Studies in Basic Sciences, Zanjan, Iran.
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MeSH Terms
Binding Sites
DNA / chemistry,  metabolism
Models, Biological*
Nucleic Acid Conformation
Nucleosomes / chemistry,  metabolism*
Stress, Mechanical*
Time Factors
Reg. No./Substance:
0/Nucleosomes; 9007-49-2/DNA

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