| Nucleoside reverse transcriptase inhibitors, mitochondrial DNA and AIDS therapy. | |
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MedLine Citation:
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PMID: 16152703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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NRTIs are cornerstones of antiretroviral therapy and perhaps the most important drugs developed for AIDS treatment. Judicious use of NRTIs in the fight against HIV infection has afforded significant clinical advances in AIDS treatment. Nonetheless, it is axiomatic to expect side effects from NRTIs as well. A principal toxicity of NRTIs relates to chronic and cumulative MT in various tissues. The long-term impact of this toxicity on affected patients is not clear except in extreme cases where morbidity was severe and mortality occurred. Because of chronicity and potential for severity, NRTI MT remains an important clinical problem. Further studies will help us unravel mechanisms of NRTI MT and the natural history of mitochondrial biogenesis in humans and other mammalian systems. |
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Authors:
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William Lewis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Antiviral therapy Volume: 10 Suppl 2 ISSN: 1359-6535 ISO Abbreviation: Antivir. Ther. (Lond.) Publication Date: 2005 |
Date Detail:
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Created Date: 2005-09-12 Completed Date: 2005-09-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9815705 Medline TA: Antivir Ther Country: England |
Other Details:
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Languages: eng Pagination: M13-27 Citation Subset: IM |
Affiliation:
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Department of Pathology, Emory University, Atlanta, GA, USA. wlewis@emory.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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drug therapy* Anti-HIV Agents / adverse effects* DNA Replication / drug effects DNA, Mitochondrial / analysis* Didanosine / adverse effects Humans Lamivudine / adverse effects Mitochondria / drug effects* Nucleosides / adverse effects* Reverse Transcriptase Inhibitors / adverse effects* Stavudine / adverse effects Zidovudine / adverse effects |
| Grant Support | |
ID/Acronym/Agency:
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HL063666/HL/NHLBI NIH HHS; HL072707/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/DNA, Mitochondrial; 0/Nucleosides; 0/Reverse Transcriptase Inhibitors; 134678-17-4/Lamivudine; 30516-87-1/Zidovudine; 3056-17-5/Stavudine; 69655-05-6/Didanosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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