Document Detail

Nucleoside phosphorylases from clostridium perfringens in the synthesis of 2',3'-dideoxyinosine.
MedLine Citation:
PMID:  20544534     Owner:  NLM     Status:  MEDLINE    
Four Clostridium perfringens phosphorylases were subcloned, overexpressed and analyzed for their substrate specificity. DeoD(1) and PunA could use a variety of purine substrates, including an antiviral drug 2',3'-dideoxyinosine (ddI). In one-pot synthesis using Clostridium phosphorylases, 2',3'-dideoxyuridine and hypoxanthine were converted to ddI at yield of about 30%.
S Christoffersen; I Serra; M Terreni; J Piskur
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  29     ISSN:  1532-2335     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  England    
Other Details:
Languages:  eng     Pagination:  445-8     Citation Subset:  IM    
Department of Cell and Organism Biology, Lund University, Lund, Sweden.
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MeSH Terms
Chromatography, High Pressure Liquid
Clostridium perfringens / enzymology*
Didanosine / chemical synthesis,  metabolism*
Pentosyltransferases / metabolism*
Reg. No./Substance:
69655-05-6/Didanosine; EC 2.4.2.-/Pentosyltransferases; EC 2.4.2.-/nucleoside phosphorylase

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