| Nucleoside phosphorylases from clostridium perfringens in the synthesis of 2',3'-dideoxyinosine. | |
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MedLine Citation:
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PMID: 20544534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four Clostridium perfringens phosphorylases were subcloned, overexpressed and analyzed for their substrate specificity. DeoD(1) and PunA could use a variety of purine substrates, including an antiviral drug 2',3'-dideoxyinosine (ddI). In one-pot synthesis using Clostridium phosphorylases, 2',3'-dideoxyuridine and hypoxanthine were converted to ddI at yield of about 30%. |
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Authors:
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S Christoffersen; I Serra; M Terreni; J Piskur |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleosides, nucleotides & nucleic acids Volume: 29 ISSN: 1532-2335 ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892832 Medline TA: Nucleosides Nucleotides Nucleic Acids Country: England |
Other Details:
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Languages: eng Pagination: 445-8 Citation Subset: IM |
Affiliation:
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Department of Cell and Organism Biology, Lund University, Lund, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, High Pressure Liquid Clostridium perfringens / enzymology* Didanosine / chemical synthesis, metabolism* Pentosyltransferases / metabolism* |
| Chemical | |
Reg. No./Substance:
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69655-05-6/Didanosine; EC 2.4.2.-/Pentosyltransferases; EC 2.4.2.-/nucleoside phosphorylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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