| Nucleoside analogue reverse transcriptase inhibitor options: a re-examination of the class. | |
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MedLine Citation:
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PMID: 17114828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The main options for dual nucleoside (or nucleotide) analogue reverse transcriptase inhibitors (nRTIs) as a component of initial antiretroviral therapy regimens are tenofovir/emtricitabine, zidovudine/lamivudine, and abacavir/lamivudine as fixed-dose combinations. Resistance to nRTIs can limit usefulness of many of the drugs in the class. Investigation of triple nRTI regimens has shown that zidovudine/lamivudine/abacavir does not provide benefits compared with dual nRTIs plus efavirenz and that others (tenofovir/lamivudine/abacavir and didanosine/lamivudine/abacavir) are associated with very high virologic failure rates. Further, 4-nRTI regimens are under investigation. The article summarizes a presentation on nRTIs made by Scott M. Hammer, MD, at the International AIDS Society-USA course in New York in March 2006. The original presentation is available as a Webcast at www.iasusa.org. |
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Authors:
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Scott M Hammer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Topics in HIV medicine : a publication of the International AIDS Society, USA Volume: 14 ISSN: 1542-8826 ISO Abbreviation: Top HIV Med Publication Date: 2006 Oct-Nov |
Date Detail:
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Created Date: 2006-11-20 Completed Date: 2007-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954650 Medline TA: Top HIV Med Country: United States |
Other Details:
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Languages: eng Pagination: 140-3 Citation Subset: IM |
Affiliation:
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Columbia University Medical Center, New York, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug Resistance, Multiple, Viral* HIV Infections / drug therapy* Humans Nucleosides Reverse Transcriptase Inhibitors / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Nucleosides; 0/Reverse Transcriptase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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