Document Detail


Nucleoplasmic calcium is required for cell proliferation.
MedLine Citation:
PMID:  17420246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ca(2+) signals regulate cell proliferation, but the spatial and temporal specificity of these signals is unknown. Here we use selective buffers of nucleoplasmic or cytoplasmic Ca(2+) to determine that cell proliferation depends upon Ca(2+) signals within the nucleus rather than in the cytoplasm. Nuclear Ca(2+) signals stimulate cell growth rather than inhibit apoptosis and specifically permit cells to advance through early prophase. Selective buffering of nuclear but not cytoplasmic Ca(2+) signals also impairs growth of tumors in vivo. These findings reveal a major physiological and potential pathophysiological role for nucleoplasmic Ca(2+) signals and suggest that this information can be used to design novel therapeutic strategies to regulate conditions of abnormal cell growth.
Authors:
Michele A Rodrigues; Dawidson A Gomes; M Fatima Leite; Wayne Grant; Lei Zhang; Wing Lam; Yung-Chi Cheng; Anton M Bennett; Michael H Nathanson
Related Documents :
12072466 - Rugose (rg), a drosophila a kinase anchor protein, is required for retinal pattern form...
14625556 - Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development.
6430736 - Localized cell death in drosophila imaginal wing disc epithelium caused by the mutation...
2911386 - A mutation that changes cell movement and cell fate in the zebrafish embryo.
21712686 - Cutaneous mycobacterial spindle cell pseudotumor: a potential mimic of soft tissue neop...
17197076 - Tangeretin and nobiletin induce g1 cell cycle arrest but not apoptosis in human breast ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-04-09
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  282     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-07-10     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17061-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / physiology*
Calcium Signaling
Cell Cycle
Cell Line
Cell Nucleus / metabolism*
Cell Proliferation*
Cytoplasm / metabolism
Fluorescent Antibody Technique
Humans
Male
Mice
Mice, Nude
Mitosis
Grant Support
ID/Acronym/Agency:
DK34989/DK/NIDDK NIH HHS; DK45710/DK/NIDDK NIH HHS; DK57751/DK/NIDDK NIH HHS; P01 DK057751/DK/NIDDK NIH HHS; P01 DK057751-01A1/DK/NIDDK NIH HHS; P30 DK034989/DK/NIDDK NIH HHS; P30 DK034989-169004/DK/NIDDK NIH HHS; R01 DK045710/DK/NIDDK NIH HHS; R01 DK045710-06A2/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
SY7Q814VUP/Calcium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Three-way stabilization of the covalent intermediate in amylomaltase, an alpha-amylase-like transgly...
Next Document:  Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance.