| Nucleophilic Aromatic Substitution, A Guided Inquiry Laboratory Experiment. | |
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MedLine Citation:
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PMID: 21197138 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Inquiry-based learning is a unique student-centered alternative to traditional instruction. This form of active learning is ideal for the organic chemistry laboratory as it encourages critical thinking and hands on problem solving to complete an experiment. Electrophilic Aromatic Substitution is immediately associated with the undergraduate organic chemistry course. However, nucleophilic aromatic substitution is not. The N-arylation of aniline derivatives is a useful reaction for implementing nucleophilic aromatic substitution into the undergraduate curriculum. Under the framework of inquiry-based learning, a straightforward procedure has been developed for the undergraduate laboratory. This experiment explores the reaction rate of the nucleophilic aromatic substitution using various electrophiles. The reaction is conducted under microwave irradiation and the experiment is completed in one laboratory setting. |
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Authors:
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Leyte L Winfield |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Chemical educator (Boise, Idaho) Volume: 15 ISSN: 1430-4171 ISO Abbreviation: - Publication Date: 2010 |
Date Detail:
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Created Date: 2011-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101541128 Medline TA: Chem Educ Country: - |
Other Details:
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Languages: ENG Pagination: 110-112 Citation Subset: - |
Affiliation:
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Spelman College, 350 Spelman Lane SW, Atlanta, GA 30314, LWinfield@spelman.edu. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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P20 MD000215-080002//NCMHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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