Document Detail

Nucleolar organizing regions (NORs) in pleomorphic adenomas of the salivary glands.
MedLine Citation:
PMID:  2169529     Owner:  NLM     Status:  MEDLINE    
The number of nucleolar organizing regions (NORs) can be used to reveal the degree of cell activity or metabolism in histopathology specimens. Forty-one cases of pleomorphic adenomas of the salivary glands were studied with a silver nitrate colloid staining method to demonstrate the NORs in the cells of the solid and duct pattern areas and in chondroid areas. Acinic and intercalated ducts cells of the surrounding normal salivary glands were also examined. The data was analyzed statistically and it was found that the cells in the solid/ductal areas had a higher cellular activity than the chondroid cells. This difference is probably directly related with the possibility of malignant transformation and the incidence of the different types of malignant pleomorphic adenomas. Furthermore, it is concluded that the number of NORs in pleomorphic adenomas to define malignancy should be done discriminating between the different histologic patterns because of their different metabolic activities.
G Landini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  19     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-10-19     Completed Date:  1990-10-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  257-60     Citation Subset:  D; IM    
Department of Oral Pathology, Kagoshima University Dental School, Japan.
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MeSH Terms
Adenoma, Pleomorphic / pathology,  ultrastructure*
Aged, 80 and over
Cell Nucleus / ultrastructure
Middle Aged
Nucleolus Organizer Region / ultrastructure*
Salivary Gland Neoplasms / pathology,  ultrastructure*

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