Document Detail

Nucleolar organizer regions in differentiated preneoplastic and neoplastic endometrial lesions.
MedLine Citation:
PMID:  10087419     Owner:  NLM     Status:  MEDLINE    
The aim of the study was the quantitative assessment of nucleolar organizer regions (NORs) in the cells of preneoplastic and neoplastic endometrial lesions. Retrospective analysis included tissue material obtained from 87 patients with simple and complex hyperplasia with or without atypia and well-differentiated stage-I endometrial adenocarcinoma. Sections were made from routine paraffin blocks and stained with AgNO3. The mean number of AgNORs per cell was determined. The results obtained indicate that the evaluation of proliferative activity of cells expressed by AgNOR count can help in the distinction between atypical hyperplasia and well-differentiated adenocarcinoma, and thus can serve as a useful pathological criterion.
S Terlikowski; A Lenczewski; S Sulkowski; M Kulikowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  47     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1999  
Date Detail:
Created Date:  1999-05-06     Completed Date:  1999-05-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  205-9     Citation Subset:  IM    
Department of Gynecology and Obstetrics, Medical University of Bialystok, Poland.
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MeSH Terms
Adenocarcinoma / ultrastructure
Cell Differentiation
Endometrial Neoplasms / ultrastructure*
Nucleolus Organizer Region / ultrastructure*
Precancerous Conditions / ultrastructure*
Retrospective Studies
Silver Staining
Tissue Embedding

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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