Document Detail


Nucleolar organizer regions (NORs) evaluation of lingual salivary glands of chronic alcoholics.
MedLine Citation:
PMID:  12406303     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chronic alcoholism has been associated with structural and physiological changes in salivary glands. Studies on a variety of pathologies have suggested that variation in number of nucleolar organizer regions (NORs) reveals conditions of cellular activity. The aim of this work was to examine, through the AgNOR technique, changes in number and size of NORs in lingual salivary glands of chronic alcoholics. METHODS: Samples of mucous and serous lingual salivary glands were obtained from tongues from autopsies of individuals whose cause of death was hepatic alcoholic cirrhosis. Lingual organs from individuals whose cause of death was accidental were used as controls. Number and size of the AgNORs and nuclear area, in ductal and acinar cells, were evaluated through a digital image analyzer. RESULTS: Statistical analysis revealed differences (P < or = 0.05) in number of AgNORs in mucous acini and ductal cells. Also, we observed changes in the area of the NORs. CONCLUSION: These results suggest that in alcoholics the activity of glandular cells, mainly in ductal epithelium, could be affected, modifying synthesis, transport and salivary secretions.
Authors:
M Severgnini; M E Ferraris; M Carranza
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  31     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-30     Completed Date:  2003-02-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  585-9     Citation Subset:  D; IM    
Affiliation:
Cátedra de Morfología Animal, Escuela de Biología, Facultad de Ciencias Exactas, Universidad Nacional de Córdoba, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alcoholism / complications,  pathology*
Case-Control Studies
Humans
Male
Middle Aged
Nucleolus Organizer Region / genetics,  pathology*
Saliva / secretion
Salivary Gland Diseases / etiology
Salivary Glands, Minor / pathology*
Silver Staining
Statistics, Nonparametric
Tongue
Transcription, Genetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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