Document Detail

Nucleolar organiser regions as a marker of growth rate in squamous cell carcinoma of the lung.
MedLine Citation:
PMID:  1481176     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The numbers of nucleolar organiser regions (AgNORs) per cell has been considered as an indicator of the cellular proliferative activity. A study was carried out to examine whether AgNOR numbers relate to the growth rate in squamous cell carcinoma of the lung. METHODS: AgNORs were stained by a one step silver method, and examined in representative paraffin sections from 45 cases of squamous cell carcinoma of the lung treated by surgical resection of the primary tumour. RESULTS: The mean (SD) AgNOR numbers per cell in squamous cell carcinomas (5.3 (0.9)) were significantly higher than those in normal bronchial epithelium (1.2 (0.1)). There was no statistical difference among tumours of different post-surgical stages (stage I = 5.2 (0.8), II = 5.9 (1.4), III A = 5.5 (1.3)). The tumour volume doubling time in these cases ranged from 74 to 208 days (120.7 (40.4)). There was a high inverse correlation between the AgNOR numbers and doubling time. CONCLUSION: The AgNOR numbers were related to the growth rate of squamous cell carcinoma of the lung. Thus the AgNOR count could be used as a useful marker for investigating the cellular proliferative activity.
S Abe; N Sukoh; S Ogura; H Kunikane; N Watanabe; I Nakajima; H Takekawa; Y Kawakami
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thorax     Volume:  47     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-02-11     Completed Date:  1993-02-11     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  778-80     Citation Subset:  IM    
Third Department of Medicine, Sapporo Medical College.
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MeSH Terms
Bronchi / pathology
Carcinoma, Squamous Cell / pathology*
Cell Division
Epithelium / pathology
Lung / pathology
Lung Neoplasms / pathology*
Middle Aged
Nucleolus Organizer Region / pathology*
Silver Staining

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