| Nucleolar organiser regions as a marker of growth rate in squamous cell carcinoma of the lung. | |
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MedLine Citation:
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PMID: 1481176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The numbers of nucleolar organiser regions (AgNORs) per cell has been considered as an indicator of the cellular proliferative activity. A study was carried out to examine whether AgNOR numbers relate to the growth rate in squamous cell carcinoma of the lung. METHODS: AgNORs were stained by a one step silver method, and examined in representative paraffin sections from 45 cases of squamous cell carcinoma of the lung treated by surgical resection of the primary tumour. RESULTS: The mean (SD) AgNOR numbers per cell in squamous cell carcinomas (5.3 (0.9)) were significantly higher than those in normal bronchial epithelium (1.2 (0.1)). There was no statistical difference among tumours of different post-surgical stages (stage I = 5.2 (0.8), II = 5.9 (1.4), III A = 5.5 (1.3)). The tumour volume doubling time in these cases ranged from 74 to 208 days (120.7 (40.4)). There was a high inverse correlation between the AgNOR numbers and doubling time. CONCLUSION: The AgNOR numbers were related to the growth rate of squamous cell carcinoma of the lung. Thus the AgNOR count could be used as a useful marker for investigating the cellular proliferative activity. |
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Authors:
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S Abe; N Sukoh; S Ogura; H Kunikane; N Watanabe; I Nakajima; H Takekawa; Y Kawakami |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Thorax Volume: 47 ISSN: 0040-6376 ISO Abbreviation: Thorax Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1993-02-11 Completed Date: 1993-02-11 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 778-80 Citation Subset: IM |
Affiliation:
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Third Department of Medicine, Sapporo Medical College. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bronchi / pathology Carcinoma, Squamous Cell / pathology* Cell Division Epithelium / pathology Female Humans Lung / pathology Lung Neoplasms / pathology* Male Middle Aged Nucleolus Organizer Region / pathology* Silver Staining |
| Comments/Corrections | |
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