| Nucleobase modifications in peptide nucleic acids. | |
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MedLine Citation:
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PMID: 17430208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peptide nucleic acid (PNA) is an oligonucleotide mimic originally designed upon a repeating N-(2-aminoethyl)glycine polyamide backbone to which nucleobase heterocycles are attached through a methylene carbonyl linkage to the alpha-amino group. These molecules possess remarkable hybridization properties with DNA or RNA forming complexes with high stability and with excellent sequence discrimination despite the substantial structural divergence from natural nucleic acids. Since the disclosure of PNA, a vibrant research community with interest in the chemistry and applications of polyamide-based nucleic acid analogs has developed. This has led to the synthesis and evaluation of a wide variety of modified polyamide nucleic acids. The focus of this report is a comprehensive review of nucleobase modifications in aminoethylglycine (aeg) PNA with reference, where appropriate, to the same modification in DNA or RNA. |
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Authors:
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Filip Wojciechowski; Robert H E Hudson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current topics in medicinal chemistry Volume: 7 ISSN: 1873-4294 ISO Abbreviation: Curr Top Med Chem Publication Date: 2007 |
Date Detail:
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Created Date: 2007-04-13 Completed Date: 2007-05-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101119673 Medline TA: Curr Top Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 667-79 Citation Subset: IM |
Affiliation:
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Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Hydrogen Bonding Peptide Nucleic Acids / chemistry* Purines / chemistry* Pyrimidines / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Peptide Nucleic Acids; 0/Purines; 0/Pyrimidines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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