Document Detail

Nucleic acids and protein content of some fetal and neonatal rat organs after insulin treatment.
MedLine Citation:
PMID:  6164549     Owner:  NLM     Status:  MEDLINE    
In 17 1/2--21 1/2 day-old fetuses and 1--4 day-old rats the DNA, RNA and protein content of the liver, heart and brain was daily investigated 6 hours after injecting approximately 40 mU . g-1 insulin. The DNA content in the mentioned organs was not affected by the insulin. The RNA content in the fetal and neonatal brain and neonatal heart was significantly elevated, while the liver RNA was not altered. Only in the 4 day-old brain did the protein content increase. The experimental dates indicate that the cell RNA content of some perinatal tissues can be elevated by insulin depending on the type of tissue and its developmental stage.
J Koppel; S Kuchár; S Mózes; K Bod'a
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endokrinologie     Volume:  77     ISSN:  0013-7251     ISO Abbreviation:  Endokrinologie     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-07-09     Completed Date:  1981-07-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370675     Medline TA:  Endokrinologie     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn
Brain Chemistry / drug effects*
DNA / analysis
Heart / drug effects
Insulin / pharmacology*
Liver / analysis*,  drug effects
Myocardium / analysis*
Proteins / analysis
RNA / analysis
Reg. No./Substance:
0/Proteins; 11061-68-0/Insulin; 63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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