| Nucleic acids modulate autoimmunity through nucleic-acid-specific toll-like receptors. | |
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MedLine Citation:
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PMID: 17073647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autoimmune diseases are believed to develop mainly from three factors comprising genetic predisposition, environmental factors and immune (dys-) regulation. In this context, specific nucleic acids of exogenous or endogenous origin that signal through nucleic acid-specific Toll-like receptors (TLRs) have gained much research attention. During ongoing autoimmune disease microbial nucleic acids contribute to flares of disease and its aggravation leading to end organ damage, through unfavourable immune modulation. Apart from exogenous sources, nucleic acid molecules of endogenous origin emerge as potential ligands for receptors of host defence, i.e. TLRs. Rapidly accumulating data on the role of nucleic acid-specific TLRs has not only provided insights about their pathogenic potential of endogenous nucleic acid molecules, but is also fuelling the development of novel immunotherapies. |
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Authors:
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Prashant S Patole; Hans-Joachim Anders |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current medicinal chemistry Volume: 13 ISSN: 0929-8673 ISO Abbreviation: Curr. Med. Chem. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-10-31 Completed Date: 2006-12-05 Revised Date: 2007-02-12 |
Medline Journal Info:
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Nlm Unique ID: 9440157 Medline TA: Curr Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 3061-7 Citation Subset: IM |
Affiliation:
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Medical Policlinic, University of Munich, Germany. hjanders@med.uni-muenchen.de. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoimmune Diseases / etiology, immunology*, therapy Autoimmunity / immunology*, physiology Humans Membrane Glycoproteins / immunology, metabolism Nucleic Acids / physiology* Receptors, Cell Surface / immunology*, metabolism Toll-Like Receptors / metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Membrane Glycoproteins; 0/Nucleic Acids; 0/Receptors, Cell Surface; 0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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