| Nucleic acid solvation: from outside to insight. | |
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MedLine Citation:
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PMID: 17574833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleic acids are polyanionic molecules that were historically considered to be solely surrounded by a shell of water molecules and a neutralizing cloud of monovalent and divalent cations. In this respect, recent experimental and theoretical reports demonstrate that water molecules within complex nucleic acid structures can display very long residency times, and assist drug binding and catalytic reactions. Finally, anions can also bind to these polyanionic systems. Many of these recent insights are provided by state-of-the-art molecular dynamics simulations of nucleic acid systems, which will be described together with relevant methodological issues. |
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Authors:
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Pascal Auffinger; Yaser Hashem |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-06-15 |
Journal Detail:
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Title: Current opinion in structural biology Volume: 17 ISSN: 0959-440X ISO Abbreviation: Curr. Opin. Struct. Biol. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-07-10 Completed Date: 2007-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107784 Medline TA: Curr Opin Struct Biol Country: England |
Other Details:
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Languages: eng Pagination: 325-33 Citation Subset: IM |
Affiliation:
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Architecture et réactivité de l'ARN, Université Louis Pasteur de Strasbourg, CNRS, IBMC, 15 rue René Descartes, 67084 Strasbourg, France. p.auffinger@ibmc.u-strasbg.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Computer Simulation Humans Models, Molecular Nucleic Acid Conformation* Nucleic Acids / chemistry, metabolism* Solubility Solvents / chemistry, metabolism* Water / chemistry, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids; 0/Solvents; 7732-18-5/Water |
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