| Nucleic acid sensing Toll-like receptors in dendritic cells. | |
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MedLine Citation:
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PMID: 18585458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dendritic cells (DCs) are crucial immune cells detecting microorganisms and linking innate and adaptive immunity. Various microorganism-derived components, including lipids, proteins, or nucleic acids, activate DCs through various pattern recognition receptors (PRRs). PRRs can principally detect non-self-components, but nucleic acid components are peculiar in that self-derived nucleic acids can also stimulate PRRs. Thus, nucleic-acid-sensing PRRs can potentially cause autoimmune responses. This potential danger comes out in certain situations, and especially nucleic-acid-induced type I interferon production contributes to the pathogenesis of autoimmune disorders. Here we review how DCs detect and respond to nucleic acid adjuvants and how self-derived nucleic acids can cause autoimmunity. Clarifying such mechanisms should contribute to the development of therapeutic manipulation for autoimmune diseases. |
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Authors:
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Katsuaki Hoshino; Tsuneyasu Kaisho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-07-01 |
Journal Detail:
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Title: Current opinion in immunology Volume: 20 ISSN: 0952-7915 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-11 Completed Date: 2009-01-06 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 408-13 Citation Subset: IM |
Affiliation:
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Laboratory for Host Defense, Research Center for Allergy and Immunology, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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metabolism Animals Autoimmunity Dendritic Cells / immunology*, metabolism Humans I-kappa B Kinase / metabolism Interferon Type I / immunology, metabolism* Myeloid Differentiation Factor 88 / metabolism NF-kappa B / metabolism Nucleic Acids / immunology*, metabolism Toll-Like Receptors / immunology*, metabolism Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I; 0/Myeloid Differentiation Factor 88; 0/NF-kappa B; 0/Nucleic Acids; 0/Toll-Like Receptors; 0/Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 2.7.11.10/I-kappa B Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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