| Nucleic acid oxidation in Alzheimer disease. | |
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MedLine Citation:
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PMID: 18258207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increasing evidence suggests that oxidative stress is intimately associated with Alzheimer disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are one of the several cellular macromolecules damaged by reactive oxygen species, particularly the hydroxyl radical. Because neurons are irreplaceable and survive as long as the organism does, they need elaborate defense mechanisms to ensure their longevity. In Alzheimer disease, however, an accumulation of nucleic acid oxidation is observed, indicating an increased level of oxidative stress and/or a decreased capacity to repair the nucleic acid damage. In this review, we present data supporting the notion that mitochondrial and metal abnormalities are key sources of oxidative stress in Alzheimer disease. Furthermore, we outline the mechanisms of nucleic acid oxidation and repair. Finally, evidence showing the occurrence of nucleic acid oxidation in Alzheimer disease will be discussed. |
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Authors:
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Paula I Moreira; Akihiko Nunomura; Masao Nakamura; Atsushi Takeda; Justin C Shenk; Gjumrakch Aliev; Mark A Smith; George Perry |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-01-18 |
Journal Detail:
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Title: Free radical biology & medicine Volume: 44 ISSN: 0891-5849 ISO Abbreviation: Free Radic. Biol. Med. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-04 Completed Date: 2008-06-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 1493-505 Citation Subset: IM |
Affiliation:
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Center for Neuroscience and Cell Biology, Institute of Physiology-Faculty of Medicine, University of Coimbra, Coimbra, Portugal. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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metabolism* Animals DNA / metabolism* DNA Repair Humans Metals / metabolism Mice Mitochondria / metabolism Oxidation-Reduction Oxidative Stress* RNA / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Metals; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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