Document Detail


Nucleic acid enzymes.
MedLine Citation:
PMID:  16257198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since the discovery of the first natural ribozyme more than 20 years ago, it has become clear that nucleic acids are not only the static depository of genetic information, but also possess intriguing catalytic activity. The number of reactions catalyzed by engineered nucleic acid enzymes is growing continuously. The versatility of these catalysts supports the idea of an ancestral world based on RNA predating the emergence of proteins, and also drives many studies towards practical applications for nucleic acid enzymes.
Authors:
Roberto Fiammengo; Andres Jäschke
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Publication Detail:
Type:  Journal Article; Review     Date:  2005-10-27
Journal Detail:
Title:  Current opinion in biotechnology     Volume:  16     ISSN:  0958-1669     ISO Abbreviation:  Curr. Opin. Biotechnol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-23     Completed Date:  2006-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100492     Medline TA:  Curr Opin Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  614-21     Citation Subset:  IM    
Affiliation:
Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Catalysis
DNA, Catalytic / chemistry*,  genetics
Directed Molecular Evolution
Nucleic Acid Conformation
RNA, Catalytic / chemistry*,  genetics
Substrate Specificity
Chemical
Reg. No./Substance:
0/DNA, Catalytic; 0/RNA, Catalytic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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