| Nucleic acid controlled catalysts of carboxylic esters hydrolysis. | |
| | |
MedLine Citation:
|
PMID: 18851909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Two Cu(2+)-binding ligands were covalently attached to termini of short DNAs. The optimal compound of this type forms a catalytically inert complex with Cu(2+). In the presence of a complementary nucleic acid the complex is decomposed forming products, which may catalyze hydrolysis of carboxylic acid esters. We have demonstrated that this process can be applied for sequence specific detection of nucleic acids. |
| | |
Authors:
|
J??nos Kov??cs; Andriy Mokhir |
Related Documents
:
|
18265199 - Overview of nucleic acid arrays. 18031029 - Relative hydrophobicity/hydrophilicity of fructose, glucose, sucrose, and trehalose as ... 10474249 - Uptake of oligonucleotides by keratinocytes. 6857739 - Temporal and dose characteristics of nucleic acids reduction in the leucocytes of irrad... 2425659 - Nucleic acid quantitation by continuous flow fluorometry. 11557819 - Matrix-induced fragmentation of p3'-n5' phosphoramidate-containing dna: high-throughput... 22411689 - Oral supplementation with dihomo-γ-linolenic acid (dgla)-enriched oil increases serum ... 16869989 - Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine o... 11485479 - Nitrogen kinetic isotope effects on the decarboxylation of 4-pyridylacetic acid. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-27 |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry letters Volume: 18 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2008 Nov |
Date Detail:
|
Created Date: 2009-10-30 Completed Date: 2009-12-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
|
Languages: eng Pagination: 5722-4 Citation Subset: IM |
Affiliation:
|
Inorganic Chemistry Institute, University of Heidelberg, In Neuenheimer Feld 270, 69120 Heidelberg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carboxylic Acids
/
chemistry* Catalysis Chromatography, High Pressure Liquid Esters Hydrolysis Nucleic Acids / chemistry* Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
| Chemical | |
Reg. No./Substance:
|
0/Carboxylic Acids; 0/Esters; 0/Nucleic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Descriptor-free molecular discovery in large libraries by adaptive substituent reordering.
Next Document: Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured n...